传明酸多肽组合物改善线粒体功能及炎性色沉的研究

Study on the improvement of mitochondrial function and inflammatory pigmentation by a translucent acid peptide composition

利用4种细胞模型,研究了单用传明酸及传明酸+精氨酸/赖氨酸多肽+谷胱甘肽(传粒亮TXATidePro™)组合物对人皮肤成纤维细胞(HFF-1)细胞代谢活性及线粒体形态学水平的影响;对人角质形成细胞(HaCaT)ATP生成、mtDNA拷贝数及细胞自噬水平的影响;对RAW264.7细胞TNF-α及IL-1β水平的影响;以及对B16F10细胞黑色素水平的影响。结果表明,传粒亮TXATidePro™组合物较对照组及单用传明酸显著促进细胞代谢活性,改善线粒体质量,提升ATP生成,降低mtDNA损伤,促进细胞自噬,抑制TNF-α及IL-1β,降低黑色素含量。传粒亮TXATidePro™组合物可通过改善皮肤细胞线粒体及自噬功能达到抗炎、提亮淡斑及抵抗炎性色沉的作用。

Four cell models were used to study the metabolic activity and mitochondrial morphology on human skin fibroblasts(HFF-1)of tranexamic acid alone and the combination of tranexamic acid+arginine/lysine peptide+glutathione(TXATidePro™),as well as the effects on ATP production,mtDNA copy number and autophagy levels in human keratinocytes(HaCaT),the effects on TNF-αand IL-1βlevels in RAW264.7 cells,and the effects on the melanin levels in B16F10 cells.The results show that compared with the control group and tranexamic acid alone,the TXATidePro™composition significantly promotes cell metabolic activity,improves mitochondrial quality,increases ATP production,reduces mtDNA damage,promotes autophagy,inhibits TNF-αand IL-1β,and reduces melanin content.It is confirmed that the TXATidePro™composition can achieve anti-inflammation,brightening blemishes and resisting inflammatory pigmentation by improving the mitochondrial and autophagy functions of the skin cells.