环泊酚应用于老年患者无痛胃肠镜的临床研究

Clinical study on the application of ciprofol in elderly patients undergoing painless gastroenteroscopy

目的观察环泊酚在老年患者无痛胃肠镜检查中的麻醉效果和不良反应。方法选择80例65岁以上行无痛胃肠镜检查的老年患者,将患者随机分为环泊酚组(C组)40例和丙泊酚组(P组)40例。每例患者均静脉注射舒芬太尼0.08μg/kg,30 s后C组给予环泊酚0.3 mg/kg、P组给予丙泊酚1.5 mg/kg。记录2组患者麻醉前(T0)、睫毛反射消失时(T1)、置入胃镜后即刻(T2)和操作结束时(T3)的心率(HR)和平均动脉压(MAP);记录2组患者检查操作时间、清醒时间、追加药物次数及静脉注射痛、呼吸抑制、呛咳、体动等不良反应发生情况。结果2组患者行胃肠镜检查操作时间、麻醉清醒时间和追加药物次数比较差异无统计学意义(P>0.05)。与T0时间点(102.6±14.1 mmHg)比较,P组患者的MAP在T1(86.0±12.5 mmHg)、T2(86.1±13.2 mmHg)、T3(92.8±12.6 mmHg)时间点明显下降,差异有统计学意义(P<0.05);与C组T1(95.9±10.8 mmHg)、T2(96.3±9.6 mmHg)时间点比较,P组的MAP在T1(86.0±12.5 mmHg)、T2(86.1±13.2 mmHg)时均明显降低(P<0.05)。C组患者静脉注射痛、呼吸抑制的发生率明显低于P组(P<0.05);2组体动和呛咳的发生率比较差异无统计学意义(P>0.05)。结论环泊酚0.3 mg/kg在老年患者胃肠镜检查中能提供和丙泊酚1.5 mg/kg相似的麻醉效果,环泊酚组的老年患者发生注射痛、血压下降、呼吸抑制的比例更低。

Objective To observe the effect of ciprofol and propofol in painless gastroenteroscopy in elderly patients.Methods A total of 80 elderly patients aged 65 or above who underwent painless gastroenteroscopy were randomly divided into a group of 40 patients receiving ciprofol(Group C)and a group of 40 patients receiving propofol(Group P).All patients were given sufentanil 0.08μg/kg,and group C was given ciprofol 0.3 mg/kg,group P was given propofol 1.5 mg/kg after 30 seconds.The heart rate(HR)and mean arterial pressure(MAP)of two groups of patients before anesthesia(T0),at the disappearance of eyelash reflex(T1),after gastroscopy insertion(T2),and at the end of the procedure(T3)were recorded.The operating time,anesthesia awakening time,number of additional medications and the adverse reactions such as injection pain,respiratory depression,cough,body movements were also recorded.Results There were no significant differences(P>0.05)in the gastroenteroscopy operating time,recovery time and number of additional medications between the two groups.Compared with T0 time point(102.6±14.1 mmHg),the MAP of group P patients significantly decreased at T1(86.0±12.5 mmHg),T2(86.1±13.2 mmHg)and T3(92.8±12.6 mmHg)time points(P<0.05).Compared with Group C at T1(95.9±10.8 mmHg),T2(96.3±9.6 mmHg)time points,the MAP of Group P decreased significantly at T1(86.0±12.5 mmHg)and T2(86.1±13.2 mmHg)time points(P<0.05).The incidences of injection pain and respiratory depression in group C were significantly lower than those in group P(P<0.05).There was no statistically significant difference in the incidences of body movements and cough between the two groups(P>0.05).Conclusions Ciprofol 0.3 mg/kg combined with sufentanil can provide anesthesia effect similar to that of propofol 1.5 mg/kg combined with sufentanil in gastroenteroscopy of elderly patients.The proportions of injection pain,blood pressure decreasing and respiratory depression in elderly patients in the ciprofol group were lower.