外周血AGGF1与冠状动脉狭窄的关系

Relation of AGGF1 in peripheral blood and coronary artery stenosis

目的探讨G补缀FHA域血管生成因子1(AGGF1)与冠状动脉狭窄的关系。方法选取2011年6月—2015年11月中国医学科学院北京协和医学院泰达国际心血管病医院冠状动脉狭窄患者116例。根据冠状动脉造影检查的结果,将116例患者分为病例组(狭窄>50%,82例)和对照组(狭窄≤50%,34例)。采用非条件多因素逐步Logistic回归分析、受试者工作特征(ROC)曲线分别评价冠状动脉狭窄>50%的危险因素和AGGF1联合高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)对冠状动脉狭窄的诊断效能。对34例对照患者进行随访,评价AGGF1对发生主要不良心血管事件(MACE)的预测价值。结果病例组AGGF1水平显著低于对照组(P<0.001)。AGGF1下降是发生冠状动脉狭窄>50%的危险因素[比值比(OR)值为0.536,95%可信区间(CI)为0.368~0.782]。AGGF1联合HDL-C、LDL-C诊断冠状动脉狭窄的曲线下面积(AUC)为0.815。对照组随访期间高AGGF1患者无MACE发生,低AGGF1患者有6例发生MACE。结论外周血AGGF1下降是冠状动脉狭窄>50%的危险因素,AGGF1联合HDL-C、LDL-C对冠状动脉狭窄具有较高的诊断效能,AGGF1降低对冠状动脉狭窄≤50%远期发生MACE或有一定的预测价值。

Objective To investigate the relation of angiogenic factor with G patch and FHA domain 1(AGGF1)in peripheral blood and coronary artery stenosis.Methods A total of 116 patients at TEDA International Cardiovascular Hospital of Chinese Academy of Medical Sciences and Peking Union Medical College from June 2011 to November 2015 were enrolled.According to coronary angiography results,the 116 patients were classified into case group(coronary artery stenosis>50%,82 cases)and control group(coronary artery stenosis≤50%,34 cases).Non-conditional multifactor stepwise Logistic regression analysis and receiver operating characteristic(ROC)curve were used to evaluate the risk factors for coronary artery stenosis>50% and the diagnostic efficacy in coronary artery stenosis of AGGF1 combined with high-density lipoprotein cholesterol(HDL-C)and lowdensity lipoprotein cholesterol(LDL-C),respectively.The 34 patients from control group were followed up,and the predictive value of AGGF1 in the occurrence of major adverse cardiovascular events(MACE)was evaluated.Results The level of AGGF1 in case group was lower than that in control group(P<0.001).Decreased AGGF1 was a risk factor for coronary artery stenosis>50%[odds ratio(OR)=0.536,95% confidence interval(CI)0.368-0.782].AGGF1 combined with HDL-C and LDL-C had an area under curve of 0.815 for the diagnosis of coronary artery stenosis.The follow-up of control group showed that there was no MACE in high AGGF1 patients and 6 cases in low AGGF1 patients.Conclusions Decreased AGGF1 in peripheral blood is a risk factor for coronary artery stenosis>50%.AGGF1 combined with HDL-C and LDL-C has a high diagnostic efficacy for the diagnosis of coronary artery stenosis,and decreased AGGF1 may have a certain predictive value for the long-term occurrence of MACE in coronary artery stenosis≤50%.