替格瑞洛联合阿司匹林治疗冠心病介入术后患者的效果

Effects of Ticagrelor combined with Aspirin in treatment of patients with coronary heart disease after interventional therapy

目的:观察替格瑞洛联合阿司匹林治疗冠心病介入术后患者的效果。方法:选取2020年1月至2021年1月于该院行介入治疗的90例冠心病患者进行前瞻性研究,按照随机数字表法将其分为观察组和对照组各45例。对照组采用阿司匹林治疗,观察组在对照组基础上联合替格瑞洛治疗,两组均持续治疗6个月。比较两组治疗前后心功能指标[左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)]水平、炎性指标[超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平、氧化应激指标[丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)]水平,以及不良反应发生率。结果:治疗后,观察组LVEDD、LVESD水平低于对照组,LVEF高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组IL-6、TNF-α、hs-CRP水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组MDA水平低于对照组,GSH-Px、SOD水平高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:替格瑞洛联合阿司匹林治疗冠心病介入术后患者可提高心功能指标水平,降低炎性指标水平,改善氧化应激指标水平,效果优于单纯阿司匹林治疗。

Objective:To observe effects of Ticagrelor combined with Aspirin in treatment of patients with coronary heart disease after interventional therapy.Methods:A prospective study was conducted on 90 patients who underwent interventional therapy for coronary heart disease in the hospital from January 2020 to January 2021.According to the random number table method,they were divided into observation group and control group,45 cases in each group.The control group was treated with Aspirin,while the observation group was treated with Ticagrelor on the basis of that of the control group.Both groups were treated for 6 months.The levels of cardiac function indexes[left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)],inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],and oxidative stress indexes[malondialdehyde(MDA),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD)],and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the levels of LVEDD and LVESD in the observation group were lower than those in the control group,the LVEF was higher than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-αand hs-CRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the level of MDA in the observation group was lower than that in the control group,the levels of GSH-Px and SOD were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Ticagrelor combined with Aspirin can improve the levels of cardiac function indexes,reduce the levels of inflammatory factors and improve the levels of oxidative stress indexes in the patients with coronary heart disease after interventional therapy.Moreover,it is superior to single Aspirin treatment.