脑心通胶囊联合丁苯酞氯化钠注射液治疗轻中度脑梗死患者的效果

Effects of Naoxintong capsules combined with Butylphthalide and Sodium chloride injection in treatment of patients with mild to moderate cerebral infarction

目的:观察脑心通胶囊联合丁苯酞氯化钠注射液治疗轻中度脑梗死患者的效果。方法:回顾性分析2021年1月至2023年11月该院收治的65例轻中度脑梗死患者的临床资料,按照治疗方法不同将其分为观察组32例和对照组33例。两组入院后均采用注射用阿替普酶进行静脉溶栓,在此基础上,对照组采用丁苯酞氯化钠注射液治疗,观察组在对照组基础上口服脑心通胶囊治疗。比较两组治疗前后神经功能[美国国立卫生院卒中量表(NIHSS)]评分、认知功能[蒙特利尔认知评估量表(MoCA)]评分、凝血指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)]水平及不良反应发生率。结果:治疗后,观察组NIHSS评分、FIB水平均低于对照组,PT、APTT均大于对照组,MoCA评分均高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:脑心通胶囊联合丁苯酞氯化钠注射液治疗轻中度脑梗死患者效果确切,可改善神经功能、认知功能及凝血功能,效果优于单用丁苯酞氯化钠注射液治疗。

Objective:To observe effects of Naoxintong capsules combined with Butylphthalide and Sodium chloride injection in treatment of patients with mild to moderate cerebral infarction.Methods:The clinical data of 65 patients with mild to moderate cerebral infarction admitted to this hospital from January 2021 to November 2023 were retrospectively analyzed.According to the different treatment plans,they were divided into observation group(32 cases)and control group(33 cases).Both groups were treated with intravenous thrombolysis with Alteplase for injection after admission.On this basis,the control group was treated with Butylphthalide and Sodium chloride injection,while the observation group was treated with Naoxintong capsules on the basis of that of the control group.The neurological function[National Institutes of Health stroke scale(NIHSS)],the cognitive function[Montreal cognitive assessment(MoCA)]score,the coagulation indexes[prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the NIHSS score and the FIB level of the observation group were lower than those of the control group,the PT and APTT were higher than those of the control group,the MoCA scores were higher than those of the control group,and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Naoxintong capsules combined with Butylphthalide and Sodium chloride injection is effective in the treatment of the patients with mild to moderate cerebral infarction,which can improve the neurological function,the cognitive function and the coagulation function.Moreover,it is superior to single Butylphthalide and Sodium chloride injection treatment.