血清D-二聚体、cTnI、NT-proBNP水平联合检测在急性心肌梗死患者预后评估中的效能

NT-proBNP levels in prognosis evaluation of patients with acute myocardial infarction

目的:观察血清D-二聚体、肌钙蛋白I(cTnI)、N末端脑钠肽前体(NT-proBNP)水平联合检测在急性心肌梗死(AMI)患者预后评估中的效能。方法:选取2020年9月至2021年10月该院收治的110例AMI患者进行横断面研究,设为观察组,根据不同预后将其分为预后良好患者71例和预后不良患者39例,另选取同期该院进行体检的110名健康者作为对照组。比较两组及不同预后AMI患者D-D、cTnI、NT-proBNP水平,绘制受试者工作特征(ROC)曲线分析D-D、cTnI、NT-proBNP水平单项及联合检测在AMI患者预后评估中的效能。结果:观察组D-D、cTnI、NT-proBNP水平均高于对照组,差异有统计学意义(P<0.05);预后不良患者D-D、cTnI、NT-proBNP水平均高于预后良好患者,差异有统计学意义(P<0.05);经ROC曲线分析结果显示,D-D、cTnI、NT-proBNP水平单项及联合检测评估AMI患者预后的曲线下面积分别为0.690、0.729、0.698、0.952,且联合检测评估AMI患者预后的效能高于三者单项检测。结论:D-D、cTnI、NT-proBNP水平联合检测在AMI患者预后评估中的效能高于三者单项检测。

Objective:To observe efficiency of combined detection of serum D-dimer,troponin I(cTnI)and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels in prognosis evaluation of patients with acute myocardial infarction(AMI).Methods:A crosssectional study was conducted on 110 patients with AMI admitted to the hospital from September 2020 to October 2021,and they were set as the observation group.According to different prognosis,they were divided into 71 patients with good prognosis and 39 patients with poor prognosis.In addition,110 healthy people who underwent physical examination in the hospital during the same period were selected as the control group.The levels of D-D,cTnI and NT-proBNP were compared between the two groups and among the AMI patients with different prognosis.The receiver operating characteristic(ROC)curve was drawn to analyze the efficiencies of single and combined detection of D-D,cTnI and NT-proBNP levels in the prognosis evaluation of the AMI patients.Results:The levels of D-D,cTnI and NT-proBNP in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of D-D,cTnI and NT-proBNP in the patients with poor prognosis were higher than those in the patients with good prognosis,and the differences were statistically significant(P<0.05).The ROC curve analysis showed that the area under the curve of single and combined detection of D-D,cTnI and NT-proBNP levels in the evaluation of the prognosis of the AMI patients were 0.690,0.729,0.698 and 0.952,respectively,and the efficiency of combined detection was higher than that of single detection.Conclusions:The efficiency of combined detection of D-D,cTnI and NT-proBNP levels in the prognosis evaluation of the AMI patients is higher than that of the single detection.