基于数据挖掘探究何永恒治疗功能性便秘的用药规律

Medication rule of He Yongheng in treatment of functional constipation:A study based on data mining

目的:通过数据挖掘技术探究何永恒教授治疗功能性便秘(FC)的用药规律。方法:收集2022年9月1日至2023年9月30日何教授门诊诊治的FC患者病案资料,运用中医传承辅助平台V3.0进行辨证分型统计,对使用药物进行频次、四气、五味、归经、关联规则及聚类分析。结果:纳入医案174则,患者174例。辨证分型频次以气滞秘、热积秘、阴虚秘为主;共涉及中药82味,药物使用频次前3位者依次为白术、火麻仁、枳壳;药物四气以温、寒、平为主,五味以苦、甘、辛为主;多归脾、胃、大肠经;药物功效频次排名前5位者为补虚、理气、清热、泻下、利水渗湿。关联规则分析得到以“白术、白芍、火麻仁、苦杏仁、枳壳、厚朴、决明子”为核心药物的组方。聚类分析发现5组药物核心组合。结论:何教授治疗FC强调行气导滞、清热利湿为核心治则,确定了“白术、白芍、火麻仁、苦杏仁、枳壳、厚朴、决明子”的核心组方,为临床治疗FC提供参考。

Objective:To investigate the medication rule of Professor He Yongheng in the treatment of functional constipation(FC)based on data mining.Methods:Medical records were collected from the patients with FC who were diagnosed and treated at the outpatient service of Professor He from September 1,2022 to September 30,2023,and Traditional Chinese Medicine Inheritance Support System V3.0 was used for syndrome differentiation and typing.The drugs used were analyzed in terms of frequency,nature,taste,and meridian entry,and association rule analysis and cluster analysis were also performed.Results:A total of 174 medical records were included,involving 174 patients in total.For syndrome differentiation and typing,Qi stagnation constipation,heat stagnation constipation,and Yin deficiency constipation.A total of 82 traditional Chinese medicine drugs were involved,and the top three drugs in terms of frequency of use were Atractylodes macrocephala Koidz.,Fructus Cannabis,and Fructus Aurantii.Most drugs had a warm,cold,or neutral nature and a bitter,sweet,or pungent taste,and they mainly entered the spleen,stomach,and large intestine meridians.The top five functions were tonifying deficiency,regulating Qi,clearing heat,purgating,and promoting diuresis and draining dampness.The association rule analysis obtained the prescriptions with the core drugs of Atractylodes macrocephala Koidz.,Radix Paeoniae Alba,Fructus Cannabis,Semen Armeniacae Amarum,Fructus Aurantii,Magnolia officinalis,and cassia seed.The cluster analysis obtained 5 core drug combinations.Conclusion:In the treatment of FC,Professor He emphasizes the core treatment principle of moving Qi and guiding stagnation and clearing heat and promoting diuresis and determines the score prescriptions of Atractylodes macrocephala Koidz.,Radix Paeoniae Alba,Fructus Cannabis,Semen Armeniacae Amarum,Fructus Aurantii,Magnolia officinalis,and cassia seed,which can provide a reference for the clinical treatment of FC.