运动改善2型糖尿病所致心肌并发症的保护效应与分子机制研究进展

Protective Effects and Molecular Mechanisms of Exercise on Reducing Myocardial Complications Induced by type 2 Diabetes Mellitus

糖尿病心肌病是2型糖尿病致死的重要原因之一,其发生发展与2型糖尿病引起的机体糖脂代谢紊乱与胰岛素抵抗密切相关。运动是防治2型糖尿病重要的非药物干预手段,其诱导的机体内源性保护效应是促进心血管健康的重要机制。本文通过文献研究,对早期2型糖尿病诱导心肌组织重塑的机制进行总结,并对运动减轻糖尿病心肌并发症的保护效应与分子机制进行综述。

Diabetic cardiomyopathy is one of the important causes of death in type 2 diabetes mellitus,which was closely related to the glycolipid metabolism disorder and insulin resistance.Exercise is an important non-drug treatment for the prevention and treatment of type 2 diabetes.The mechanism under exercise-induced cardiovascular protection is probably related to the endogenous protective effect.The researches on mechanisms of early myocardial remodeling induced by type 2 diabetes were summed up in this article.Meanwhile,we summarized the protective effects and molecular mechanisms of exercise-induced cardioprotection of diabetic cardiomyopathy.