康妇消炎栓联合抗生素治疗慢性盆腔炎的疗效及对炎性因子和血液流变学的影响

Effect of Kangfu Xiaoyan suppository combined with antibiotics in the treatment of chronic pelvic inflammatory disease and its effect on inflammatory factors and blood rheology

目的观察康妇消炎栓联合抗生素治疗慢性盆腔炎的疗效及对炎性因子和血液流变学的影响。方法选取2021年7月—2023年1月在泰安市妇幼保健院治疗的慢性盆腔炎患者112例,采用随机数字表法分为观察组和对照组,每组56例。对照组给予头孢克肟颗粒联合甲硝唑片治疗,观察组在对照组基础上联合康妇消炎栓治疗,2组均治疗15 d。比较2组临床疗效、治疗前后症状体征积分、炎性因子水平、血液流变学指标及不良反应。结果观察组治疗总有效率为96.43%,高于对照组的78.57%(χ^(2)=8.163,P=0.004)。治疗15 d后,2组腹痛、带下增多、附件增厚、盆腔压痛、盆腔包块、盆腔积液积分及单核细胞趋化蛋白-1、白介素-2、白介素-21、C反应蛋白、肿瘤坏死因子-α、全血黏度、血浆黏度、纤维蛋白原水平均低于治疗前,且观察组低于对照组(P<0.01)。观察组不良反应总发生率为8.93%,与对照组的7.14%比较差异无统计学意义(χ^(2)=0.121,P=0.728)。结论康妇消炎栓联合抗生素治疗慢性盆腔炎的临床疗效较高,可改善患者临床症状体征、炎性反应程度和血液流变学,且不会增加不良反应。

Objective To observe effect of Kangfu Xiaoyan suppository combined with antibiotics in the treatment of chronic pelvic inflammatory disease and its effect on inflammatory factors and blood rheology.Methods A total of 112 patients with chronic pelvic inflammatory disease who were treated in Taian Maternity and Child Health Hospital from July 2021 to January 2023 were selected,and they were divided into observation group and control group by randomized numerical table method,with 56 cases in each group.The control group was treated with cefixime granules combined with metronidazole tablets,and the observation group was treated with Kangfu Xiaoyan suppository on the basis of the control group,and both groups were treated for 15 days.The clinical efficacy,symptoms and signs,inflammatory factor level,blood rheology indexes before and after treatment,and adverse reactions of the two groups were compared.Results The total effective rate of treatment in the observation group was 96.43%,which was higher than 78.57%in the control group(χ^(2)=8.163,P=0.004).After 15 days of treatment,the two groups had abdominal pain,increased tape,thickening of adnexa,pelvic pressure,pelvic mass,pelvic fluid score and MCP-1,IL-2,IL-21,CRP,TNF-α,WBV,PV,and Fib levels were lower than those before treatment on average,and the observation group was lower than the control group(P<0.01).The total incidence of adverse reactions in the observation group was 8.93%,and the difference was not statistically significant when compared with 7.14%in the control group(χ^(2)=0.121,P=0.728).Conclusion Kangfu Xiaoyan suppository combined with antibiotics in the treatment of chronic pelvic inflammatory disease has high clinical efficacy,can improve patients′clinical signs and symptoms,the degree of inflammatory reaction and blood rheology,and does not increase the adverse effects.