基于铁死亡理论探讨中医药治疗骨质疏松症的研究进展

Research Progress on Osteoporosis Treated with Traditional Chinese Medicine Based on Ferroptosis Theory

铁死亡是一种铁离子参与的新型程序性细胞死亡方式。骨质疏松症作为一种高发代谢性疾病,与铁死亡之间关系密切。中医药对骨质疏松症的防治,具有独特优势。铁死亡理论指导下,如何选择最优的中医药方法,以提高骨质疏松症的治疗效率,是该领域研究亟待解决的问题。铁死亡的主要调控机制与骨质疏松相关。花椒、姜黄、丹参、黄芪、补肾还精方及电针等对骨质疏松症有治疗作用的中医药方法,均可实现不同途径下对铁死亡的干预。推测所纳入的单味中药及复方、电针等均可通过干预铁死亡对骨质疏松症产生调节作用。

Ferroptosis is a novel iron ion-involved programmed cell death pathway.Osteoporosis,as a common metabolic disorder,has a close relationship with ferroptosis.Traditional Chinese medicine(TCM)possesses unique advantages in the prevention and treatment of osteoporosis.Under the guidance of ferroptosis theory,how to select the optimal TCM methods to improve the treatment efficiency of osteoporosis is a pressing issue in this field of research.The main regulatory mechanisms of ferroptosis are related to osteoporosis.TCM therapies,such as Zanthoxyli Pericarpium,Curcumae Longae Rhizoma,Salviae Miltiorrhizae Radix et Rhizoma,Astragali Radix,and Bushen Huanjing Formula,as well as electroacupuncture,have therapeutic effects on osteoporosis and can intervene in ferroptosis through different pathways.It is inferred that the included single drugs,compound formulas,electroacupuncture,and other TCM therapies can regulate osteoporosis by intervening in ferroptosis.