痰热清注射液辅助治疗脓毒症并急性肺损伤的临床疗效

Clinical efficacy of Tanreqing injection in the adjuvant treatment of sepsis complicated with acute lung injury

目的观察痰热清注射液辅助治疗脓毒症并急性肺损伤的临床疗效。方法选取2017年8月—2018年7月于贵阳市第一人民医院接受治疗的脓毒症并急性肺损伤患者140例,按照随机数字表法分为常规治疗组(n=70)和痰热清注射液组(n=70)。常规治疗组给予常规西医措施治疗,痰热清注射液组在常规治疗组基础上联合痰热清注射液,2组均治疗7 d。比较2组治疗前与治疗第3、7天血清炎性指标[C反应蛋白(CRP)、降钙素原(PCT)、白介素(IL)-6、IL-17、IL-33及高迁移率族蛋白B1(HMGB1)]、肺损伤评分(LIS)、急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、呼吸功能指标[血管外肺水指数(EVLWI)、肺血管通透性指数(PVPI)]、血气指标[动脉血氧饱和度(SaO_(2))、动脉血氧分压(PaO_(2))]。结果治疗第3、7天,2组血清CRP、PCT、IL-6、IL-17、IL-33、HMGB1水平低于治疗前,且痰热清注射液组低于常规治疗组(P<0.01);2组LIS、APACHEⅡ评分低于治疗前,且痰热清注射液组低于常规治疗组(P<0.01);2组EVLWI、PVPI低于治疗前,且痰热清注射液组低于常规治疗组(P<0.01);2组SaO_(2)、PaO_(2)高于治疗前,且痰热清注射液组高于常规治疗组(P<0.01)。结论痰热清注射液辅助治疗脓毒症并急性肺损伤的临床疗效显著,可更有效地减轻机体炎性反应,提高肺功能,增加血氧含量,进而改善患者的身体状况。

Objective To investigate the clinical efficacy of Tanreqing injection in the adjuvant treatment of sepsis complicated with acute lung injury.Methods A total of 140 sepsis patients complicated with acute lung injury who were treated in the First People′s Hospital of Guiyang from August 2017 to July 2018 were selected,and they were divided into the conventional treatment group(n=70)and the Tanreqing group(n=70)according to random number table method.Patients in the conventional treatment group were treated with conventional western medical methods for 7 days,and patients in the Tanreqing group were treated with Tanreqing injection for 7 days on the basis of the conventional treatment group.The two groups were compared in terms of serum inflammatory factors(CRP,PCT,IL-6,IL-17,IL-33,HMGB1),LIS,APACHEⅡscore,respiratory function indexes(EVLWI,PVPI),blood gas indexes(SaO_(2),PaO_(2))before treatment and at the 3rd,7th day of the treatment.Results At the 3rd and the 7th day of the treatment,serum levels of CRP,PCT,IL-6,IL-17,IL-33,HMGB1 of the two groups were lower than those before treatment,and the Tanreqing group were lower than those of the conventional treatment group(P<0.01);LIS and APACHEⅡscore of the two groups were lower than those before treatment,and the Tanreqing group were lower than those of the conventional treatment group(P<0.01);EVLWI,PVPI of the two groups were lower than those before treatment,and the Tanreqing group were lower than those of the conventional treatment group(P<0.01);SaO_(2),PaO_(2) of the two groups were higher than those before treatment,and the Tanreqing group were higher than those of the conventional treatment group(P<0.01).Conclusion The clinical efficacy of Tanreqing injection in the treatment of sepsis complicated with acute lung injury is remarkable,which can effectively reduce the inflammatory reaction of the body,promote pulmonary function and blood oxygen,and improve the physical condition of patients.