痰热清注射液联合注射用阿莫西林钠克拉维酸钾治疗小儿支气管肺炎的效果及安全性

Clinical effect and safety of Tanreqing injection combined with amoxicillin sodium and clavulanate potassium for injection in the treatment of pediatric bronchopneumonia

目的 观察痰热清注射液联合注射用阿莫西林钠克拉维酸钾治疗小儿支气管肺炎的临床效果及安全性。方法 回顾性选取2020年1月—2022年12月鹰潭市中医院收治的支气管肺炎患儿70例,根据用药方法分为西药组与中药联合组,各35例。西药组患儿予注射用阿莫西林钠克拉维酸钾,中药联合组患儿在西药组基础上予痰热清注射液,2组均持续用药1周。比较2组临床疗效,症状及体征消失时间,用药前后肺功能指标、免疫指标、血清炎性因子及不良反应。结果 中药联合组总有效率高于西药组(97.14%vs. 77.14%,χ^(2)=4.590,P=0.032)。中药联合组体温恢复正常时间、呼吸功能改善时间及咳嗽、肺部啰音、肺部病灶消失时间均短于西药组(P<0.05)。用药1周后,2组第1秒用力呼气容积、用力肺活量、呼气流量峰值及免疫球蛋白A、免疫球蛋白G、免疫球蛋白M、血清白介素-2、白介素-10水平高于用药前,血清肿瘤坏死因子-α水平低于用药前,且中药联合组高/低于西药组(P<0.01)。中药联合组与西药组不良反应总发生率比较,差异无统计学意义(5.71%vs. 8.57%,P=1.000)。结论 小儿支气管肺炎采用痰热清注射液联合注射用阿莫西林钠克拉维酸钾治疗的临床效果显著,能够明显改善患儿的肺功能,提高免疫功能,减轻炎性反应,进而促进症状及体征快速消失,且安全性较高。

Objective To observe the clinical effect and safety of Tanreqing injection combined with amoxicillin sodium and clavulanate potassium for injection in the treatment of pediatric bronchopneumonia.Methods A total of 70 children with bronchopneumonia admitted to Yingtan Hospital of Traditional Chinese Medicine from January 2020 to December 2022 were retrospectively selected,and they were divided into western medicine group and TCM combination group according to medication method,with 35 cases in each group.Children in western medicine group were given amoxicillin sodium and clavulanate potassium for injection,and children in TCM combination group were given Tanreqing injection on the basis of western medicine group.Both groups continued to medicated for 1 week.Clinical efficacy,symptom and sign disappearance time,pulmonary function indexes,immunity indexes,serum inflammatory factors before and after medication,and adverse reactions were compared between the two groups.Results The total effective rate of TCM combination group was higher than that of western medicine group(97.14%vs.77.14%,χ^(2)=4.590,P=0.032).Time for body temperature returned to normal,respiratory function improvement time and disappearance time of cough,lung rales,lung lesions in TCM combination group were shorter than those in western medicine group(P<0.05).After 1 week of medication,FEV_(1),FVC,PEF and levels of IgG,IgM,serum IL-2,IL-10 in the two groups were higher than those before medication,and serum level of TNF-αwas lower than that before medication,and the indexes in TCM combination group were higher/lower than those in western medicine group(P<0.01).There was no significant difference of incidence of adverse reactions between the TCM combination group and western medicine group(5.71%vs.8.57%,P=1.000).Conclusion The clinical effect of Tanreqing injection combined with amoxicillin sodium and clavulanate potassium for injection is remarkable in the treatment of pediatric bronchopneumonia,which can significantly improve the pulmonary function of children,improve immune function,reduce inflammatory response,and promote the rapid disappearance of symptoms and signs,and with higher safety.