枯草杆菌二联活菌颗粒联合消旋卡多曲颗粒治疗小儿轮状病毒肠炎的临床效果

Effect of combined bacillus subtilis and enterococcus faecium granules with multivitamines,live and racecadotril granules in the treatment of infant with rotavirus enteritis

目的 观察枯草杆菌二联活菌颗粒联合消旋卡多曲颗粒治疗小儿轮状病毒肠炎(RE)的临床效果。方法 选取2021年12月—2022年12月汉川市妇幼保健院收治的RE患儿64例,按随机数字表法分为单一西药组与微生物制剂组,各32例。单一西药组给予消旋卡多曲颗粒,微生物制剂组在单一西药组基础上联合枯草杆菌二联活菌颗粒治疗,2组均连续治疗1周。比较2组临床疗效,治疗前后血清炎性指标[白介素-1β(IL-1β)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、高迁移率族蛋白B1(HMGB1)、晚期糖基化终末产物(AGEs)],不良反应。结果 微生物制剂组总有效率高于单一西药组(96.88%vs. 75.00%,χ^(2)=4.655,P=0.031)。治疗1周后,2组血清IL-1β、IL-6、TNF-α、HMGB1及AGEs水平低于治疗前,且微生物制剂组低于单一西药组(P均<0.01)。单一西药组与微生物制剂组不良反应总发生率比较,差异无统计学意义(15.63%vs. 12.50%,P=1.000)。结论 枯草杆菌二联活菌颗粒联合消旋卡多曲颗粒治疗RE患儿的临床效果显著,可有效改善患儿微炎症状态,减轻感染程度,且安全性较高。

Objective To observe the effect of combined bacillus subtilis and enterococcus faecium granules with multivitamines,live and racecadotril granules in the treatment of infant with RE.Methods Sixty-four cases of infant with RE admitted in Hanchuan Maternal and Child Health Hospital from December 2021 to December 2022 were selected,and they were divided into the single western medicine group and the microbiology preparation group according to the random number table method,32 cases in each group.The single western medicine group was treated with racecadotril granules,and the microbiology preparation group was treated with combined bacillus subtilis and enterococcus faecium granules with multivitamines,live on the basis of the single western medicine group,and both groups were treated continuously for 1 week.Clinical efficacy,serum inflammatory indexes(IL-1β,IL-6,TNF-α,HMGB1,AGEs)before and after treatment,and adverse reactions were compared between the two groups.Results The total effective rate in the microbiology preparation group was higher than that in the single western medicine group(96.88%vs.75.00%,χ^(2)=4.655,P=0.031).After 1 week of treatment,levels of serum IL-1β,IL-6,TNF-α,HMGB1 and AGEs were lower than those before treatment in the two groups,and the microbiology preparation group were lower than those in the single western medicine group(P<0.01).There was no statistically significant difference in the total incidence of adverse reactions between the single western medicine group and the microbiology preparation group(15.63%vs.12.50%,P=1.000).Conclusion Combined bacillus subtilis and enterococcus faecium granules with multivitamines,live and racecadotril granules have a significant efficacy in the treatment of infant with RE,it can effectively improve the microinflammatory state of infant,reduce the degree of infection,and it has high safety.