胃癌分子分型的研究进展及相关联系

Advances and correlation in molecular classification of gastric cancer

胃癌是常见的消化道恶性肿瘤,高度异质性是胃癌诊断和治疗的棘手问题之一。目前对于传统胃癌分型的治疗策略并不完善,因此对于胃癌分子分型的研究是极其必要的。本文回顾了癌症基因组图谱(TCGA)及亚洲癌症研究小组(ACRG)两种里程碑式的分子分型,并从单细胞RNA测序、lncRNA、表观遗传学、免疫浸润等方面进一步阐述胃癌不同的分子分型,阐述每个分型不同的分子特征和生物学行为以及不同分型之间的联系,并探寻其可能作用的基因靶点和机制通路,为改善胃癌患者预后并开展针对特定亚型的靶向治疗提供依据。

Gastric cancer is a common malignant tumor of digestive tract,and its high heterogeneity is one of the thorny problems in the diagnosis and treatment of gastric cancer.At present,the traditional treatment strategies for gastric cancer classification are not perfect,so the research on molecular classification of gastric cancer is extremely necessary.In this paper,two landmark molecular classifications of The Cancer Genome Atlas(TCGA)and Asian Cancer Research Group(ACRG)were reviewed,and different molecular classifications of recent gastric cancer were further elaborated from the aspects of single-cell RNA sequencing,lncRNA,epigenetics,and immune infiltration.The different molecular characteristics and biological behaviors of each type as well as the relationship between different subtypes were described.The gene targets and mechanism pathways of their action may be explored,which helps improve the outcomes and provides basis for targeted therapy for specific subtypes.