老年人小腿围、HCAR与认知障碍的因果中介分析--基于CLHLS2014数据

Causal mediation analysis of Calf Circumference,HCAR and Cognitive Impairment in older adults-based on CLHLS2014 data

目的探究小腿围与认知障碍的关系及超敏C反应蛋白/白蛋白比值(hypersensitive C-reactive protein/albumin ratio,HCAR)的中介作用。方法筛选2014年CLHLS数据库中的1784例老年人数据。通过中文版简易精神状态量表(Chinese version of the brief mental state examination,cMMSE)评估认知功能。使用R软件进行数据处理和分析,Bootstrap抽样法验证中介效应。结果校正多种协变量后,小腿围与认知障碍呈显著负相关(OR=0.951,95%CI:0.933~0.970),HCAR在其中起到中介作用(中介效应比例为0.022,95%CI:0.002~0.060)。结论小腿围与认知障碍之间存在负关联,HCAR起中介作用。该发现对预防和干预认知障碍有重要意义。

Objective This study aims to investigate the relationship between calf circumference and cognitive impairment and to study the mediating role of the hypersensitive C-reactive protein(hs-CRP)/albumin ratio(HCAR).Methods Data in the 2014 CLHLS database were analyzed,and 1784 study participants were finally included in this study.Cognitive function was assessed by the Chinese version of the brief mental state examination(cMMSE).Data were processed and analysed using R software,and mediating effects were verified using Bootstrap sampling.Results After correcting for multiple factors,calf circumference was significantly negatively associated with cognitive impairment(OR-0.951,95%CI:0.933-0.970),in which HCAR played a mediating role(mediating effect ratio 0.022,95%CI:0.002-0.060).Conclusion There is a negative association between calf circumference and cognitive impairment,in with HCAR plays a mediating role.This finding has important implications for the prevention and intervention of cognitive impairment.