新生儿化脓性脑膜炎病原菌分布情况调查分析

Investigation and analysis of pathogenic bacteria distribution in neonates with purulent meningitis

目的了解新生儿化脓性脑膜炎病原菌分布,为有效防控提供参考。方法通过病原学标本检测方法,对某医院新生儿重症监护病房(NICU)收治的化脓性脑膜炎患儿病原学标本进行检测与分析。结果本次调查共诊断早发型和迟发型新生儿化脓性脑膜炎病例130例,从确诊患儿送检的病原学标本中共检出病原菌110株,包括17种细菌,革兰阳性菌与阴性菌比例相当。在110例阳性标本中,早发型病例占54例,迟发性病例占56例。检出前5位的病原菌依次为大肠埃希菌、无乳链球菌、肺炎克雷伯菌、产单核李斯特菌和凝固酶阴性葡萄球菌。结论该医院NICU收治的化脓性脑膜炎患儿病原菌既有阳性菌又有阴性菌,两者比例相当,应有针对性加强防控措施。

Objective To understand the distribution of pathogenic bacteria in neonatal purulent meningitis and to provide reference for effective prevention and control.Methods Pathogenic specimen detection method was used to detect and analyze the pathogen specimens of children with purulent meningitis admitted to the neonatal intensive care unit(NICU)of a hospital.Results A total of 130 cases of early-onset and late-onset neonatal purulent meningitis were diagnosed in this survey.From the pathogenic specimens submitted by confirmed neonatal patients,110 pathogens were detected,including 17 types of bacteria,and the proportion of Gram-positive and Gram-negative bacteria was equivalent.Among the 110 positive specimens,54 were early-onset cases and 56 were late-onset cases.The top 5 pathogens were Escherichia coli,Streptococcus agalactiae,Klebsiella pneumoniae,Listeria monocytogenes,and coagulase negative Staphylococcus.Conclusions The pathogens of neonatal meningitis admitted to NICU in this hospital contain both Gram-positive and Gram-negative bacteria,and targeted prevention and control measures should be strengthened.