甲地孕酮联合运动疗法在晚期肺癌恶病质患者中的临床疗效及对生活质量的影响

Clinical efficacy and impact on quality of life of medroxyprogesterone combined with exercise therapy in patients with advanced stage lung cancer cachexia

目的 探讨甲地孕酮、营养支持联合运动疗法在晚期肺癌恶病质患者中的临床疗效及对患者生活质量的影响。方法 选取2021年1月~2023年1月于青州市人民医院肿瘤科住院的晚期肺癌恶病质患者60例,随机分为对照组30例和观察组30例;对照组患者予以甲地孕酮+营养支持疗法,观察组患者予以甲地孕酮+营养支持联合运动疗法,30d为1个治疗周期。比较治疗后两组患者的临床自觉症状、卡氏评分、患者体重及营养状况(血清白蛋白、血清前白蛋白)。结果 联合干预治疗后,观察组临床症状改善明显优于对照组(P<0.05),两组患者干预治疗后临床疗效均较治疗前明显改善(P<0.05),观察组患者卡氏评分优于对照组(P<0.05),联合干预治疗后两组患者体重及营养状况较治疗前明显改善(P<0.05),且观察组体重及营养状况优于对照组(P<0.05)。结论 甲地孕酮联合运动疗法能改善晚期肺癌恶病质患者的临床症状,增加体重,提高KPS评分,改善营养状况及提高患者生活质量。

Objective To Exploring the clinical efficacy of progesterone,nutritional support combined with exercise therapy in patients with advanced stage lung cancer cachexia,and the impact of combined therapy on patient quality of life.Methods Sixty patients with advanced lung cancer cachexia admitted to the Oncology Department of Qingzhou People's Hospital from January 2021 to January 2023 were randomly divided into a control group(30 cases) and an observation group(30 cases);Patients in the control group were treated with medroxyprogesterone and nutritional support therapy,while patients in the observation group were treated with medroxyprogesterone,nutritional support and exercise therapy,each with a 30 day treatment cycle.The changes in clinical symptoms,Karst score,body weight,and nutritional status(serum albumin,serum prealbumin) of two groups of advanced lung cancer cachexia patients after treatment were compared.Results After combined intervention treatment,the clinical symptom improvement of the observation group was significantly better than that in the control group(P<0.05),and the clinical efficacy of both groups after intervention treatment was significantly improved compared to before treatment(P<0.05).The Kashgar score of the observation group was better than that of the control group(P<0.05).After combined intervention treatment,the weight and nutritional status of the two groups of patients were significantly improved compared to before treatment(P<0.05),and the weight and nutritional status of the observation group were better than those of the control group(P<0.05).Conclusion The combination of methylprogesterone and exercise therapy can improve the clinical symptoms,weight gain,KPS score,nutritional status,and quality of life of patients with advanced lung cancer cachexia.