摘要
大量研究已证实阿尔茨海默病是一种血脑屏障(BBB)功能障碍相关性疾病,如何通过恢复BBB结构完整性、改善其生理机能,提高AD的转归和预后,必将为该慢病的预防与治疗带来新的视角和机遇。本文就AD的BBB结构功能变化与发病机制、生物标记物及治疗靶点三方面的研究进展综述如下。
Numerous studies have confirmed that Alzheimer's disease is a disorder related to dysfunction of blood brain barrier(BBB).How to improve the physiological function of BBB by restoring its structural integrity,and then improve the outcome and prognosis of AD will certainly bring new perspectives and opportunities for the prevention and treatment of this chronic disease.In this article,we review the research progress on AD from three aspects including the structural and functional changes of BBB and its pathogenesis,biomarkers and therapeutic targets.
作者
申杰
徐桂华
SHEN Jie;XU Guihua(Department of Neurology,the Third People's Hospital of Shenzhen Longgang District,Shenzhen 518112,China;Department of Neurology,Dongguan Binhaiwan Central Hospital,Dongguan 523900,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2024年第11期1602-1606,共5页
The Journal of Practical Medicine
基金
国家自然科学基金项目(编号:81860228)
内蒙古自治区自然科学基金项目(编号:2018MS03004)
东莞市社会发展科技项目(编号:20211800904462)
东莞市滨海湾中心医院高水平科研孵化基金项目(编号:2022001)。
关键词
阿尔茨海默病
血脑屏障
生物标记物
治疗靶点
Alzheimer's disease
blood-brain barrier
biomarkers
therapeutic targets
