角膜塑形镜对青少年近视患者眼生物学参数的影响

Effect of orthokeratology on the biological parameters of adolescent myopia patients

目的观察近视青少年患者通过角膜塑形术(英文Orthokeratology简称OK镜)前后的生物学参数变化。方法本研究纳入31例(57只眼)近视青少年患者, 对患者视力、角膜曲率、角膜散光、角膜不规则系数、中央角膜厚度、角膜内皮细胞密度、眼轴长度进行戴镜前、戴镜后1个月、戴镜后3个月的观察随访, 统计分析和比较3组时间点的差异。结果患者在戴镜后视力改善, 角膜曲率平坦化, 角膜散光大小改变无统计学差异但角膜不规则系数增大, 中央角膜厚度和角膜内皮细胞密度改变无统计学差异, 眼轴长度在戴镜1个月内轻微缩短而在戴镜3个月后恢复戴镜前状态。结论角膜塑形镜对近视的矫正效果显著, 在短期内持续使用角膜塑形镜是安全有效的。

Objective To observe the changes in biological parameter after the use of orthokeratology.Methods Thirty-one subjects(fifty-seven eyes)were enrolled and fitted for OK lens.Visual acuity,the curvature of the cornea,the astigmatism of the cornea,the irregular coefficients of the cornea,the central corneal thickness,the density of corneal endothelial cell and the axial lengths of eyes were measured before and 1 month,3 months after orthokeratology.These data at three time points were analyzed statiscally.Results All subjects had better visual acuity significantly after orthokeratology.The cornea were flatten after orthokeratology.There was no significant change in the amount of cornea astigmatism,but the irregular coefficients of the cornea rose.There was no significant change in the central corneal thickness of the cornea and the density of corneal endothelial cell after orthokeratology.The axial lengths of eyes were shorten after 1 month's use,and changed back to the baseline after 3 month's use.Conclusions Orthokeratology could correct myopia effectively,and the short-term use of orthokeratology was safe.