复方沙棘籽油栓治疗慢性宫颈炎合并高危型HPV感染有效性和安全性Meta分析

Meta-analysis on the Efficacy and Safety of Seabuckthorn Seed Oil Suppository in the Treatment of Chronic Cervicitis Complicated by Human Papilloma Virus Infection

目的基于Meta分析系统评价复方沙棘籽油栓联合rhIFNα-2b栓治疗慢性宫颈炎(CC)合并高危型人乳头瘤病毒(HPV)感染的有效性与安全性。方法检索中国知识资源总库(CNKI)、中国生物医学文献服务系统(SinoMed)、中国学术期刊数据库(万方数据)、中文科技期刊数据库(VIP)、中国临床试验注册中心、PubMed、Cochrane Library建库至2022年7月1日收录的复方沙棘籽油栓治疗CC合并高危型HPV感染的随机对照试验(RCT)文献,进行数据提取和文献质量评价,运用RevMan5.4软件进行Meta分析和亚组分析。结果共纳入RCT文献10篇,试验组和对照组患者共1432例。与单独使用重组人干扰素(rhIFN)α-2b栓相比,联用复方沙棘籽油栓可显著提高CC合并高危型HPV感染的临床总有效率(RR=1.20,95%CI[1.15,1.26],P=0.79,I^(2)=0%)和治愈率(RR=1.40,95%CI[1.18,1.66],P=0.67,I2=0%),差异均有统计学意义;复方沙棘籽油栓联合rhIFNα-2b栓治疗可提高HPV转阴率,疗程越长效应越大,54天组(RR=1.14,95%CI[1.06,1.22],P=0.32,I^(2)=14%)、60天组(RR=1.61,95%CI[1.26,2.06],P=0.75,I^(2)=0%),84天组(RR=1.83,95%CI[1.26,2.64],P=0.05,I2=66%)。结论复方沙棘籽油栓联合rhIFNα-2b栓治疗CC合并高危型HPV感染的临床总有效率、治愈率和HPV转阴率均优于单用rhIFNα-2b栓,且无不良反应事件发生。

Objective To evaluate the clinical efficacy and safety of seabuckthorn seed oil suppository(CSSOS)combined with recombinant human interferon(rhIFN)α-2b gel in the treatment of chronic cervicitis(CC)complicated by high-risk human papillomavirus(HR-HPV)infection.Methods Randomized controlled trials(RCTs)on CSSOS combined with rhIFNα-2b gel in the treatment of CC complicated by HR-HPV infection were retrieved from CNKI,SinoMed,Wanfang Data,VIP,PubMed,Cochrane Library databases from establishment of the databases to 1st,July 2022.The data were extracted and literature quality was evaluated.RevMan 5.4 software was used for meta-analysis and subgroup analysis.Results A total of 10 RCTs were included.There were a total of 1432 patients in the experimental group and control group.Compared with using rhIFNα-2b gel alone,CSSOS combined with recombinant rhIFNα-2b gel could significantly improve the clinical total efficiency rate of CC complicated by HR HPV(RR=1.20,95%CI[1.15,1.26],P=0.79,I^(2)=0%)and cure rate(RR=1.40,95%CI[1.18,1.66],P=0.67,I2=0%),with statistical significance.CSSOS combined with rhIFNα-2b gel could improve the HPV conversion rate,and the longer the treatment course,the greater the efficacy,with the 54 day group(RR=1.14,95%CI[1.06,1.22],P=0.32,I^(2)=14%),the 60 day group(RR=1.61,95%CI[1.26,2.06],P=0.75,I^(2)=0%),and the 84 day group(RR=1.83,95%CI[1.26,2.64],P=0.05,I^(2)=66%).Conclusion Clinical total effective rate,cure rate,and HPV conversion rate of CSSOS combined with rhIFNα-2b gel in the treatment of CC complicated by HR-HPV infection are better than using rhIFNα-2b gel alone,without adverse reactions.