原发性失眠患者MRI研究进展

Research Progress of MRI in Patients with Primary Insomnia

原发性失眠是指无特定的心理、生理或物质相关原因,患者难以入睡或难以维持睡眠,常伴有白天精神及能力严重受损。近年来原发性失眠患者数量不断增加,从而引起了广泛关注,国内外研究者应用最新的磁共振成像(magnetic resonance imaging,MRI)方法对原发性失眠的神经生物学机制进行了大量研究。目前磁共振技术在原发性失眠的研究方面不仅包括已经逐步应用于临床的磁共振氢质子波谱成像、弥散张量成像、三维动脉自旋标记技术,还包括仍处于研究状态的结构性核磁共振成像、功能性核磁共振成像,本文将就上述核磁共振成像技术对原发性失眠的研究进展进行综述。

Primary insomnia is the difficulty of fling asleep,maintaining sleep,or non-restorative sleep in the absence of a specific physical,psychological,or materially related cause,accompanied by significant impairment of daytime function.In recent years,an increasing number of patients with primary insomnia,which has caused wide public concern,researchers applied at home and abroad the latest method of magnetic resonance imaging(MRI)and a lot of work on the neurobiological mechanisms of primary insomnia.At present,the research of magnetic resonance technology in primary insomnia includes not only magnetic resonance hydrogen proton spectroscopy imaging,diffusion tensor imaging,and threedimensional arterial spin labeling technology,but also structural magnetic resonance imaging and functional magnetic resonance imaging,which are still under study.This article reviews the research progress of MRI in primary insomnia.