聚焦临床关键科学问题充实科学基金资助体系

Enrich Science Funding System by Focusing on Key Clinical Scientific Issues

临床科学研究是我国医学界实现“原始创新”与提供“中国证据”“中国数据”“中国方案”的关键抓手。近30年来,我国在临床研究监管体系、基地与平台、队伍建设以及成果产出等方面取得长足进步。但我国临床研究的源头创新和临床转化能力相对薄弱。国家自然科学基金(以下简称“科学基金”)作为推动基础研究源头创新的核心力量,在我国医学科学发展中始终发挥关键引领作用。面向我国临床研究领域亟待解决的重大需求、关键临床科学问题和技术瓶颈,如何引领医学科学领域的研究方向,并以此契合临床重大需求及应用转化、激发临床研究者的创新源动力、鼓励基于临床关键科学问题的自由探索临床研究,是科学基金需要直面和解决的时代命题。本文就我国临床科学研究的现状、科学基金资助临床研究的模式与效能、科学基金支持临床研究实施过程中可能存在的问题与解决方案等做了初步调研并提出相关建议。

Clinical scientific research is the key to achieving“original innovation”and providing Chinese evidence,Chinese data in medical community.In the past 3 decades,China has made great progress in clinical research supervision system,research centers and platform,team building,as well as achievement output.However,in view of the late start,the original innovation and clinical transformation ability of clinical research in China are relatively weak.As the core force to promote the source innovation of basic research,the National Science Foundation has played a key leading role in the development of medical science in China.Facing the major demands,key clinical problems and bottleneck problems that need to be solved urgently in China's clinical research field,how to lead the research direction in the field of medical science,so as to better meet the major clinical needs and application transformation,stimulate the innovation source power of clinical researchers,and encourage free exploration of clinical research based on key clinical scientific issues.It is a proposition of the times that Medical Science Foundation needs to face and solve.This paper makes preliminary research and suggestions on the current situation of clinical scientific research in China,the mode and efficacy of clinical research funded by science foundations,and the possible problems and solutions of clinical research supported by science funds.