托法替布与依那西普治疗活动性强直性脊柱炎的随机对照临床研究

A Randomized Controlled Clinical Study of Tofacitib versus Etanercept in the Treatment of Active Ankylosing Spondylitis

目的探讨托法替布及依那西普在活动性强直性脊柱炎中的治疗效果。方法选取2023年6—12月在菏泽市立医院接受治疗的70例活动性强直性脊柱炎患者作为研究对象,根据用药方案分成两组,对照组患者应用依那西普注射治疗,观察组患者应用托法替布治疗,比较两组疗效、炎性指标、预后情况。结果两组总有效率(93.33%vs 96.67%)对比,差异无统计学意义(χ^(2)=0.351,P>0.05)。两组血细胞沉降率、C-反应蛋白、肿瘤坏死因子-α水平比较,差异无统计学意义(P均>0.05)。两组患者的视觉模拟法评分、Bath强直性脊柱炎活动指数、Bath强直性脊柱炎功能指数比较,差异无统计学意义(P均>0.05)。结论托法替布及依那西普治疗活动性强直性脊柱炎均能够保证整体疗效,可有效抗炎,对于减轻患者痛苦及改善其预后可发挥积极作用,可根据具体情况选择治疗方案。

Objective To explore the therapeutic effects of controlled tofacitib and etanercept in active ankylosing spondylitis.Methods A total of 70 patients with active ankylosing spondylitis who received treatment in Heze Municipal Hospital from June to December 2023 were selected as the study objects and were divided into two groups according to the medication regimens.Patients in the control group were treated with etanercept injection therapy,and patients in the observation group were treated with tofacitib.The efficacy,inflammatory indexes and prognosis of the two groups were compared.Results There was no statistically significant difference in total effective rate between the two groups(93.33%vs 96.67%)(χ^(2)=0.351,P>0.05).There were no statistically significant differences in the blood sedimentation rate,C-reactive protein and tumor necrosis factor-αlevels between the two groups(all P>0.05).There was no statistically significant difference in Visual Analogue Scale scores,Bath Ankylosing Spondylitis Disease Activity Index and Bath Ankylosing Spondylitis Functional Index between the two groups(all P>0.05).Conclusion Tofacitib and etanercept in the treatment of active ankylosing spondylitis are able to ensure the overall efficacy,can be effective anti-inflammatory,and can play a positive role in reducing the pain of patients and improving their prognosis,and can be selected according to the specific circumstances of the treatment program.