比较米非司酮与黄体酮治疗围绝经期功能性子宫出血的临床效果

Clinical Effect of Mifepristone and Progesterone in the Treatment of Peri menopause Functional Uterine Bleeding

目的探究在围绝经期功能性子宫出血中,应用米非司酮和黄体酮治疗效果的差异性。方法随机抽取2020年7月—2022年7月临沂市中医医院收治的67例围绝经期功能性子宫出血患者为研究对象,采用随机数表法分为对照组33例和观察组34例。对照组采取传统方法黄体酮治疗,观察组应用米非司酮治疗。比较两组治疗效果、止血时间、相关临床指标、性激素水平、不良反应情况。结果观察组总有效率为97.06%,比对照组的75.76%更高,差异有统计学意义(χ^(2)=4.831,P<0.05)。观察组控制止血时间、完全止血时间均短于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组月经量、子宫内膜厚度均低于对照组,血红蛋白浓度高于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组孕酮、雌二醇、促黄体生成素、促卵泡激素均低于对照组,差异有统计学意义(P均<0.05)。观察组不良反应总发生率比对照组更低,差异有统计学意义(P<0.05)。结论在围绝经期功能性子宫出血的治疗当中,采用米非司酮的治疗方案,能有效提高治疗总有效率,缩短止血时间,改善相关临床指标及性激素水平,同时不良反应较少,临床效果及安全性都比较理想。

Objective To explore the difference effect between mifepristone and progesterone in the treatment of peri-menopause functional uterine bleeding.Methods A total of 67 patients with peri-menopause functional uterine bleeding in Linyi Hospital of Traditional Chinese Medicine from July 2020 to July 2022 were randomly selected as the study object and divided into control group(33 cases)and observation group(34 cases)by random number table method.The control group was treated with progesterone and the observation group was treated with mifepristone.The therapeutic effect,hemostatic time,related clinical indexes,sex hormone levels and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.06%,which was higher than 75.76%of the control group,and the difference was statistically significant(χ^(2)=4.831,P<0.05).The time of controlled hemostasis and complete hemostasis in the observation group were shorter than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,the menstrual volume and endometrial thickness in the observation group were lower than those in the control group,and the hemoglobin concentration was higher than that in the control group,and the differences were statistically significant(all P<0.05).After treatment,progesterone,estradiol,luteinizing hormone and follicle-stimulating hormone in observation group were lower than those in control group,and the differences were statistically significant(all P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion In the treatment of peri-menopause functional uterine bleeding,the use of mifepristone treatment program can effectively improve the total effective rate of treatment,shorten the hemostatic time,improve the relevant clinical indicators and sex hormone levels,while the adverse reactions are less,the clinical effect and safety are relatively ideal.