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他克莫司联合厄贝沙坦在狼疮性肾炎治疗中的应用分析

Tacrolimus Combined with Irbecartan in the Treatment of Lupus Nephritis
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摘要 目的评价狼疮性肾炎的临床用药期间,他克莫司联合应用厄贝沙坦的干预效果。方法便利选取2022年9月—2023年9月青岛市即墨区人民医院收治的72例狼疮性肾炎患者作为研究对象。依照随机数表法分为参照组、研究组,每组36例。参照组单独应用他克莫司治疗,研究组应用他克莫司+厄贝沙坦治疗。比较两组的免疫功能、肾功能、临床疗效。结果研究组用药后的CD3^(+)、CD8^(+)指标低于参照组,CD4^(+)高于参照组,差异有统计学意义(P均<0.05)。用药后,除血清白蛋白指标外,研究组其余肾功能检验指标均低于参照组,差异有统计学意义(P均<0.05)。研究组总缓解率为94.44%,高于参照组的75.00%,差异有统计学意义(χ^(2)=5.257,P<0.05)。结论狼疮性肾炎患者的临床用药中,选择他克莫司、厄贝沙坦联合治疗,可取得更好效果。联合给药不仅能够提高患者的总缓解率,改善其肾功能,调节免疫功能,最终改善患者预后。 Objective To evaluate the intervention effect of glucocorticoid(tacrolimus)combined with irbecartan during clinical administration of lupus nephritis.Methods A total of 72 patients with lupus nephritis admitted to Qingdao Jimo District People's Hospital from September 2022 to September 2023 were conveniently selected as the research objects.According to the random number table method,they were divided into reference group and study group,with 36 cases in each group.The reference group was treated with tacrolimus alone,and the study group treated with tacrolimus+irbesartan.The immune function,renal function and clinical efficacy of the two groups were compared.Results The CD3^(+) and CD8^(+) indexes of the study group were lower than those of the reference group,and the CD4^(+) was higher than that of the reference group,and the differences were statistically significant(all P<0.05).After treatment,except for serum albumin index,the other renal function test indexes in the study group were lower than those in the reference group,and the differences were statistically significant(all P<0.05).Total remission rate,the study group was 94.44%,which was higher than that of the reference group(75.00%),and the differences were statistically significant(χ^(2)=5.257,P<0.05).Conclusion The combination of tacrolimus and irbecartan can achieve better treatment results in the clinical administration of lupus nephritis patients.Combined administration can not only improve the overall response rate of patients,but also significantly improve their renal function,enhance the efficacy of immune regulation,and ultimately improve the prognosis of patients.
作者 黄斐斐 高明 张少华 HUANG Feifei;GAO Ming;ZHANG Shaohua(Department of Cardiology Ⅱ,Jimo District People's Hospital,Qingdao,Shandong Province,266200 China;Department of Nephrology,Jimo District People's Hospital,Qingdao,Shandong Province,266200 China)
出处 《中外医疗》 2024年第11期87-89,97,共4页 China & Foreign Medical Treatment
关键词 狼疮性肾炎 他克莫司 厄贝沙坦 肾功能 Lupus nephritis Tacrolimus Irbecartan Renal function
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