瑞舒伐他汀结合氯吡格雷治疗冠心病不稳定型心绞痛患者的临床价值分析

Clinical Value of Rosuvastatin Combined with Clopidogrel in the Treatment of Patients with Unstable Angina Pectoris of Coronary Heart Disease

目的分析冠状动脉粥样硬化性心脏病(简称冠心病)不稳定型心绞痛患者采用瑞舒伐他汀结合氯吡格雷治疗的效果。方法方便选取2021年10月—2023年10月新泰市人民医院收治的112例冠心病不稳定型心绞痛患者为研究对象,以随机数表法分为对照组、观察组,每组56例,对照组采用辛伐他汀结合氯吡格雷治疗,观察组采用瑞舒伐他汀结合氯吡格雷治疗。对比两组治疗前后炎性因子水平、血管内皮功能指标、心绞痛发作情况。结果治疗后,观察组炎性因子水平、血管内皮功能指标均优于对照组,差异有统计学意义(P均<0.05);治疗后,观察组心绞痛发作次数为(2.53±0.44)次/周,少于对照组的(3.41±0.51)次/周,发作持续时间为(4.55±1.47)min/次,短于对照组(6.13±1.52)min/次,差异有统计学意义(t=9.776、5.591,P均<0.001)。结论对冠心病不稳定型心绞痛患者采用瑞舒伐他汀结合氯吡格雷治疗可调节患者炎性因子水平以及血管内皮功能,有助于改善患者心绞痛发作情况。

Objective To analyze the effect of rosuvastatin combined with clopidogrel in patients with unstable angina pectoris of coronary heart disease.Methods A total of 112 patients with unstable angina pectoris of coronary heart disease treated in Xintai People's Hospital from October 2021 to October 2023 were conveniently selected as the study objects,and they were divided into control group and observation group by random number table method,with 56 cases in each group.The control group was treated with simvastatin combined with clopidogrel,and the observation group was treated with rosuvastatin combined with clopidogrel.The levels of inflammatory factors,vascular endothelial function and angina pectoris were compared between the two groups before and after treatment.Results After treatment,the inflammatory factors and vascular endothelial function indexes in the observation group were better than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,the frequency of angina pectoris attacks in the observation group was(2.53±0.44)times per week,less than that in the control group(3.41±0.51)times per week,and the duration of angina pectoris attacks in the observation group was(4.55±1.47)min/time shorter than that in the control group(6.13±1.52)min/time,and the differences were statistically significant(t=9.776,5.591,both P<0.001).Conclusion Rosuvastatin combined with clopidogrel can regulate the level of inflammatory factors and vascular endothelial function in patients with unstable angina pectoris of coronary heart disease,and help to improve the incidence of angina pectoris.