基于迷走神经调控效应的中医药防治心房颤动研究进展

Research progress in the prevention and treatment of atrial fibrillation using traditional Chinese medicine based on the regulatory effect of the vagus nerve

心房颤动(房颤)是临床上常见的心律失常之一,目前其发病机制尚未明确,近年来自主神经系统机制作为触发和维持房颤的重要因素受到界内广泛重视,临床实践发现长期药物干预、射频消融及侵入性手术操作带来了难以忽视的副作用,因此围绕自主神经系统探索非药物非消融的新型房颤治疗方法是学界探索的前沿热点,研究发现中医通过干预自主神经功能在低强度迷走神经刺激治疗房颤方面发挥着举足轻重的作用,但目前临床上仍缺乏个体化的低强度迷走神经刺激治疗方案,因此低强度迷走神经刺激的方案仍需进一步探索和研究。本文从自主神经与房颤的关系、自主神经治疗房颤的临床证据及中医药通过自主神经干预房颤3个方面进行综述。

Atrial fibrillation(AF)is one of the common arrhythmias in clinical practice,and its pathogenesis is not yet clear.In recent years,the mechanism of the autonomic nervous system as an important factor in triggering and maintaining atrial fibrillation has received extensive attention in the community.Clinical practice has shown that longterm drug intervention,radiofrequency ablation,and invasive surgical procedures have brought side effects that are difficult to ignore.Therefore,exploring new non-drug and non-ablation treatment methods for atrial fibrillation with respect to the autonomic nervous system is a cutting-edge hot topic in the academic community.Research has shown that traditional Chinese medicine plays a crucial role in the treatment of atrial fibrillation by intervening in autonomic nervous function through low-intensity vagus nerve stimulation.However,there is still a lack of personalized low-intensity vagus nerve stimulation treatment protocols in clinical practice.Therefore,further exploration and research are needed for lowintensity vagus nerve stimulation protocols.This article reviews the relationship between the autonomic nervous system and atrial fibrillation,clinical evidence of autonomic nervous system in the treatment for atrial fibrillation,and the intervention of traditional Chinese medicine in atrial fibrillation through the autonomic nervous system.