中医药治疗肺癌癌因性疲乏的研究概况与思考

Research Overview and Reflection on the Treatment of Cancer-Related Fatigue in Lung Cancer by Traditional Chinese Medicine

肺癌癌因性疲乏(CRF)是肺癌患者最常见的并发症之一,对患者的生活质量以及远期预后有重要影响。目前西医对本病的发病机制研究尚未明晰,非药物疗法临床疗效不佳,药物治疗毒副作用显著。中医药作为防治肺癌CRF的优势策略,具有靶点多、安全性高、副作用少等独特优势,临床应用前景广阔。肺癌CRF可归属中医“虚劳”范畴,是多种病因导致的以五脏六腑精气耗伤、气血阴阳虚损为主要病机的病证,主要表现为乏力、虚弱、焦虑、抑郁等症状。本文从中医古籍出发,系统梳理了肺癌CRF病因、病机、治则与遣方用药,总结了学界治疗肺癌CRF的研究概况,探讨了中医药治疗肺癌CRF的最新研究,并对改善肺癌CRF的研究前景进行展望,以期为后续研究提供理论支撑。

Cancer-related fatigue(CRF)is one of the most common complications of lung cancer patients,which has an important impact on patients'quality of life and long-term prognosis.At present,the pathogenesis of this disease is not clear in Western medicine,non-drug therapy has poor clinical efficacy,and drug therapy has significant toxic and side effects.Traditional Chinese medicine(TCM)has significant advantages in the prevention and treatment of this disorder.It has many targets,high safety,fewer side effects and other unique advantages,and has broad clinical application prospects.CRF in lung cancer belongs to the category of“consumptive disease”in TCM.It has a variety of causes,with five viscera,six bowels,qi,blood,yin and yang deficiency as the main pathogenesis of disease pattern,and mainly manifested by fatigue,weakness,anxiety,depression and other symptoms.Based on the ancient books of TCM,this paper systematically combs the etiology,pathogenesis,treatment and formulae of lung cancer CRF,summarizes the research situation,discusses the latest research in TCM,and looks forward to the research prospect of improving lung cancer CRF,in order to provide theoretical support for the follow-up research.