靶向线粒体在癌症治疗中的作用研究进展

Research progress on the role of mitochondrial targeting in cancer treatment

靶向机体亚单位治疗是当前癌症治疗的新型策略,也是现代分子药理学研究和发展的重点方向。线粒体是产生能量的场所和细胞的代谢中心,肿瘤细胞具有代谢异常的特征,这使得开发靶向线粒体的化合物成为新的抗肿瘤研究方向。此外,基于线粒体在肿瘤代谢中的多重作用,靶向线粒体治疗药物特异性较高,对正常组织的不良反应较低。本文综述了线粒体与癌症之间的联系及目前应用较多的靶向线粒体的小分子在癌症治疗中的作用,为癌症治疗提供一种新的策略。

Body subunit-targeting therapy is a new strategy for current cancer treatment and a key direction of modern molecular pharmacology research and development.Mitochondria are the sites of energy-yielding and the metabolic centers of cells.Tumor cells have the characteristics of metabolic abnormalities,which makes the development of compounds targeting mitochondria as a new anti-tumor research strategy.In addition,based on the multiple roles of mitochondria in tumor metabolism,targeted mitochondrial therapy drugs are essential to increase drug specificity and reduce adverse effects on normal tissues.This article reviewed the relation between mitochondria and cancer,and summarized the role of the small molecules that are currently used to target mitochondria in cancer treatment,so as to provide a new treatment strategy for cancer.