摘要
慢性应激对人类心身疾病的作用与机制是应激研究领域的热点。建立动物模型模拟人类慢性应激状态,在应激反应原理、相关疾病发生机制、临床治疗和药物研发方面有重要意义。本文综述了国内外常用的慢性应激动物模型,总结了应激原分类、动物选择、模型建造、病理表现和评价指标,讨论了各种模型的优缺点及应用进展,期望为研究慢性应激反应的模型选择提供参考。
The effect and mechanism of chronic stress on psychosomatic diseases are important topics in stress research.The establishment of animal models to simulate human chronic stress is of great significance to investigations of stress responses,the pathogenesis of related diseases,clinical treatment,and drug development.In this paper,animal models of chronic stress commonly used in China and abroad are reviewed;the classification of stressors,animal selection,model construction,pathological manifestations,and evaluation indexes are summarized;and the advantages and disadvantages and application of various models are discussed.The paper provides a reference for the study and selection of models of chronic stress response.
作者
岳小琪
李玉婷
姜淼
赵自刚
牛春雨
YUE Xiaoqi;LI Yuting;JIANG Miao;ZHAO Zigang;NIU Chunyu(Institute of Microcirculation&Basic Medical College,Hebei North University,Zhangjiakou 075000,China;Hebei Key Laboratory of Acute and Severe Disease Pathogenesis and Intervention,Zhangjiakou,075000;Basic Medical College,Hebei Medical University,Shijiazhuang 050017)
出处
《中国比较医学杂志》
CAS
北大核心
2024年第4期147-155,共9页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金面上项目(82270524)
河北省硕士在读研究生创新能力培养资助项目(CXZZSS2024128)。
关键词
慢性应激
动物模型
评价指标
chronic stress
animal model
evaluation indices