清心开窍方联合卡巴拉汀治疗轻中度阿尔兹海默病痰浊蒙窍型的疗效观察

The curative effect of Qingxin Kaiqiao prescription combined with capalatine in the treatment of mild and moderate Alzheimer's disease with Phlegm turbidity-mongolian orifice syndrome

目的探讨清心开窍方联合卡巴拉汀治疗轻中度阿尔兹海默病痰浊蒙窍型的疗效。方法选取2021年7月至2023年7月本院收治的轻中度阿尔兹海默病痰浊蒙窍型患者80例,随机分为观察组和对照组,各40例。对照组接受卡巴拉汀治疗,观察组采用清心开窍方联合卡巴拉汀治疗,连续治疗2个月后比较两组临床疗效、认知功能、日常生活能力量表(ADL)评分和中医证候积分。结果观察组总有效率为90%,明显高于对照组72.5%(P<0.05);治疗后两组简易精神状态检查量表评分(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分、ADL评分均明显高于治疗前(P<0.05),且观察组明显高于对照组(P<0.05);两组治疗后中医证候积分明显低于治疗前(P<0.05),且观察组低于对照组(P<0.05)。结论清心开窍方联合卡巴拉汀治疗轻中度阿尔兹海默病痰浊蒙窍型效果明显,可进一步提高临床疗效,减轻患者认知功能障碍,改善日常生活能力。

Objective To investigate the curative effect of Qingxin Kaiqiao prescription combined with capalatine in the treatment of mild and moderate Alzheimer's disease with Phlegm turbidity-mongolian orifice syndrome.Methods A total of 80 mild to moderate AD patients who were admitted to our hospital from July 2021 to July 2023 were randomly divided into the observation group(40 patients)and the control group(40 patients).The control group treated with capalatine,while the observation group received treatment with Qingxin Kaiqiao prescription combined with capalatine.After 2 months of continuous treatment,the clinical efficacy,Montreal cognitive assessment scale(MoCA)scores,mini mental state examination(MMSE)scores,daily life scale(ADL)scores and traditional Chinese medicine(TCM)syndrome points of the two groups were compared.Results The total effective rate of the observation group was 90%,higher than the control group(72.5%)(P<0.05).After treatment,the MMSE,MoCA and ADL scores of the two groups were higher than before treatment(P<0.05),and the observation group was higher than the control group(P<0.05).After treatment,the TCM syndrome scores of the two groups were lower than before treatment(P<0.05),and the observation group was lower than the control group(P<0.05).Conclusion Qingxin Kaiqiao prescription combined with capalatine has a significant effect on the treatment of mild to moderate AD with Phlegm turbidity-mongolian orifice syndrome,which can further improve clinical efficacy,cognitive function and daily living ability of patients.