腺样囊性癌动物模型的研究进展

Research progress on animal models of adenoid cystic carcinoma

腺样囊性癌(ACC)是头颈部常见的恶性肿瘤,具有较高的神经侵袭率、局部复发率和远处转移率,预后较差。动物模型是研究肿瘤发病机制和有效药物的理想模型,本文总结了国内外近些年来头颈部涎腺和泪腺ACC动物模型的建立方法和优缺点,为合理选择和优化动物模型奠定基础。

Adenoid cystic carcinoma(ACC)is a common malignant tumor in the head and neck,with a high rate of neuroinvasion,local recurrence,and distant metastasis,and a poor prognosis.Animal models are ideal models for studying the pathogenesis of tumors and effective drugs.This article summarizes the methods and advantages and disadvantages of establishing animal models for head and neck salivary and lacrimal gland ACC in recent years,laying a foundation for the rational selection and optimization of animal models.