乌鲁木齐某社区育龄女性促甲状腺激素水平升高与血压升高关联研究

Study on the relationship between elevated thyroid stimulating hormone level and elevated blood pressure in women of childbearing age in a community of Urumqi

目的探讨乌鲁木齐某社区育龄女性促甲状腺激素(TSH)水平升高与血压升高的关系。方法本研究采取整群随机抽样方法,选取2020年5月乌鲁木齐某社区进行慢性病流行病学调查的受试者(共2561例)中资料完整的育龄期女性866例为研究对象,年龄20~49岁,检测身高、体重、腹围、臀围、血压、空腹血糖、TSH水平。采用Logistic回归方法分析TSH水平升高与血压升高的关系。结果本研究纳入866例育龄女性,根据孕前血压状况可分为正常血压组(424例,49.0%)和血压升高组(442例,51.0%)。血压升高组年龄、腹围、臀围、腰臀比、体重指数、TSH水平[(3.4±2.8)mIU/L比(2.9±2.1)mIU/L]均明显高于血压正常组,差异均有统计学意义(均P<0.05)。以血压水平(0=正常,1=升高)为因变量,以年龄、腹围、臀围、体重指数、空腹血糖、TSH为自变量,分为模型1(未控制其他变量)和模型2(控制年龄、腹围、臀围、体重指数、空腹血糖)分别探讨TSH水平与血压升高的关系,结果显示无论是否控制其他因素,TSH水平升高均与血压升高相关,TSH水平升高可能是血压升高的危险因素(模型1:比值比=1.53,95%置信区间:1.09~2.13,P=0.012;模型2:比值比=1.45,95%置信区间:1.03~2.04,P=0.030)。结论育龄女性TSH水平升高与血压升高相关,TSH水平升高可能是血压升高的危险因素。

Objective To investigate the relationship between elevated thyroid stimulating hormone(TSH)level and elevated blood pressure in women of childbearing age in a community of Urumqi.Methods In this study,cluster random sampling method was used to select 866 women of childbearing age with complete data from 2561 subjects who participated in an epidemiological survey of chronic diseases in a community of Urumqi in May 2020,and the age ranged from 20 to 49 years.The height,body mass,abdominal circumference,hip circumference,blood pressure,fasting blood glucose and TSH levels were measured.Logistic regression method was used to analyze the relationship between elevated TSH level and elevated blood pressure.Results A total of 866 women of childbearing age were included in this study.According to the blood pressure status before pregnancy,they were divided into normal blood pressure group(424 cases,49.0%)and elevated blood pressure group(442 cases,51.0%).Age,abdominal circumference,hip circumference,waist-hip ratio,body mass index and TSH level[(3.4±2.8)mIU/L vs(2.9±2.1)mIU/L]in the elevated blood pressure group were significantly higher than those in the normal blood pressure group(all P<0.05).The blood pressure level(0=normal,1=elevated)was used as the dependent variable,and age,abdominal circumference,hip circumference,body mass index,fasting blood glucose,and TSH were used as independent variables.Model 1(without controlling other variables)and model 2(controlling age,waist circumference,hip circumference,body mass index and fasting blood glucose)were used to explore the relationship between TSH level and elevated blood pressure.The results showed that elevated TSH level was associated with elevated blood pressure regardless of whether other factors were controlled.Elevated TSH level may be a risk factor for elevated blood pressure(model 1:odds ratio=1.53,95%confidence interval:1.09-2.13,P=0.012;model 2:odds ratio=1.45,95%confidence interval:1.03-2.04,P=0.030).Conclusion Elevated TSH level is associated with elevated blood pressure in women of childbearing age,and elevated TSH level may be a risk factor for elevated blood pressure.