栀豉温胆汤联合荆花胃康胶丸对反流性食管炎患者症状改善情况及炎症因子水平的影响

Effect of Zhichi Wendan Decoction Combined with Jinghua Weikang Capsules on the Improvement of Symptoms and Levels of Inflammatory Factors in Patients with Reflux Esophagitis

目的:探讨栀豉温胆汤联合荆花胃康胶丸对反流性食管炎(RE)患者症状改善情况及炎症因子水平的影响。方法:用随机数字表法将2022年9月—2023年9月在武威市凉州医院就诊的100例RE患者分成两组,观察组、对照组,各50例。对照组予予雷贝拉唑治疗,在上述治疗上,观察组予栀豉温胆汤联合荆花胃康胶丸治疗。对比两组症状改善情况、炎症因子水平、血清胃动素(MTL)与胃泌素(GAS)水平。结果:治疗后,两组反流性疾病问卷(RDQ)总积分均较治疗前降低,且观察组RDQ总积分更低,差异均有统计学意义(P<0.05)。治疗后,两组白介素(IL)-17、IL-6与肿瘤坏死因子-α(TNF-α)均较治疗前下降,且观察组IL-6、IL-17与TNF-α均较对照组低,差异均有统计学意义(P<0.05)。治疗后,两组MTL与GAS均较治疗前升高,且观察组MTL与GAS均较对照组高,差异均有统计学意义(P<0.05)。结论:栀豉温胆汤联合荆花胃康胶丸治疗RE可减轻炎症反应,调节血清MTL与GAS水平,改善临床症状。

Objective:To explore the effect of Zhichi Wendan Decoction combined with Jinghua Weikang Capsules on the improvement of symptoms and the level of inflammatory factors in patients with reflux esophagitis(RE).Method:A total of 100 RE patients who received treatment at Liangzhou Hospital in Wuwei City from September 2022 to September 2023 were divided into two groups by random number table method,the observation group and the control group,with 50 cases in each group.The control group was treated with Rabeprazole,while the observation group was treated with Zhichi Wendan Decoction combined with Jinghua Weikang Capsules.The improvement of symptoms,levels of inflammatory factors,serum motilin(MTL)and gastrin(GAS)levels were compared between the two groups.Result:After treatment,the total score of the reflux disease questionnaire(RDQ)in both groups were decreased compared to those before treatment,and the total score of RDQ in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).After treatment,interleukin(IL)-17,IL-6,and tumor necrosis factor-α(TNF-α)in two groups were decreased compared to those before treatment,and IL-6,IL-17,and TNF-αin the observation group were decreased compared with the control group,the differences were statistically significant(P<0.05).After treatment,MTL and GAS in both groups were increased compared to those before treatment,MTL and GAS in the observation group were higher compared with the control group,the differences were statistically significant(P<0.05).Conclusion:The combination of Zhichi Wendan Decoction and Jinghua Weikang Capsules can alleviate inflammation,regulate serum MTL and GAS levels,and improve clinical symptoms in the treatment of RE.