非酒精性脂肪性肝病与相关肝细胞肝癌研究进展

Research Progress of Non-alcoholic Fatty Liver Disease and Related Hepatocellular Carcinoma

非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是一种以肝脏脂肪沉积为主的代谢性疾病,可导致肝脏脂肪变性、肝硬化及肝细胞肝癌(hepatocellular carcinoma,HCC)的发生发展。NAFLD与NAFLD相关HCC有着相似的多元化发病机制:胰岛素抵抗、脂肪代谢、遗传易感性、免疫失调、肠道菌群紊乱、铁沉积等。近些年随着NAFLD的患病率的增加,NAFLD相关HCC患病率也逐年增加,因此提早监测预防NAFLD相关HCC发生显得尤为重要。本文综述了NAFLD相关HCC的流行病学、发病机制、监测及预防,为认识NAFLD相关的HCC现状及预防奠定了基础。

Non-alcoholic fatty liver disease(NAFLD)is a metabolic disease dominated by fat deposition in the liver,which can lead to the occurrence and development of hepatic steatosis,cirrhosis and hepatocellular carcinoma(HCC).NAFLD and NAFLD-related HCC share similar diversified pathogenesis,including insulin resistance,fat metabolism,genetic susceptibility,immune dysregulation,intestinal flora disorder,iron deposition,and so on.In recent years,with the increase of the prevalence of NAFLD,the prevalence of NAFLD-related HCC has also increased year by year,so early monitoring and prevention of NAFLD-related HCC are particularly important.This article reviews the epidemiology,pathogenesis,surveillance and prevention of NAFLD-related HCC,which lays a foundation for understanding the current situation and prevention of NAFLD-related HCC.