酸枣仁汤及右佐匹克隆对“肝血不足、虚热内扰”失眠患者睡眠质量及HAMA、HAMD评分的影响

Effects of Suanzaoren Decoction and Dexzopiclone on Sleep Quality,HAMA and HAMD Scores in Patients with Insomnia with"Deficiency of Liver Blood and Internal Disturbance of Deficient Heat"

目的:研究酸枣仁汤及右佐匹克隆对“肝血不足、虚热内扰”失眠患者睡眠质量及汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评分的影响。方法:选择2022年5—12月在南安市康复院接受治疗的“肝血不足、虚热内扰”失眠患者138例作为观察对象,按随机数字表法分为观察组及对照组,各69例。对照组予以右佐匹克隆治疗,观察组在对照组基础上予以酸枣仁汤治疗,两组均治疗1个月。对比两组疗效、匹兹堡睡眠质量指数(PSQI)和失眠严重程度(SPIEGEL量表)评分、HAMA和HAMD评分,以及不良反应发生情况和睡眠满意度。结果:观察组总有效率为98.55%,较对照组的86.96%高(P<0.05)。治疗后两组PSQI、SPIEGEL量表评分均较治疗前更低,且观察组均较对照组更低(P<0.05)。治疗后两组HAMA和HAMD评分均较治疗前更低,且观察组均较对照组更低(P<0.05)。观察组不良反应总发生率为8.70%,与对照组的11.59%比较,差异无统计学意义(P>0.05)。观察组患者睡眠满意度为98.55%,较对照组的85.51%明显更高(P<0.05)。结论:酸枣仁汤联合右佐匹克隆对“肝血不足、虚热内扰”失眠患者的疗效较好,可改善其睡眠质量、睡眠满意度及HAMA、HAMD评分,安全性较高。

Objective:To study the effects of Suanzaoren Decoction and Dexzopiclone on sleep quality,Hamilton anxiety scale(HAMA)and Hamilton depression scale(HAMD)scores in patients with insomnia with"deficiency of liver blood and internal disturbance of deficient heat".Method:A total of 138 patients with insomnia with"deficiency of liver blood and internal disturbance of deficient heat"who received treatment in Nan’an Rehabilitation Hospital from May to December 2022 were selected as the observation objects,and were divided into observation group and control group according to random number table method,with 69 cases in each group.The control group was treated with Dexzopiclone,and the observation group was treated with Suanzaoren Decoction on the basis of the control group.Both groups were treated for 1 month.Efficacy,Pittsburgh sleep quality index(PSQI)and insomnia severity(SPIEGEL scale)scores,HAMA and HAMD scores,adverse reactions and sleep satisfaction were compared between the two groups.Result:The total effective rate of the observation group was 98.55%,which was higher than 86.96%of the control group(P<0.05).After treatment,PSQI and SPIEGEL scale scores in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).After treatment,HAMA and HAMD scores in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).The total incidence of adverse reactions in the observation group was 8.70%,compared with 11.59%in the control group,the difference was not statistically significant(P>0.05).The sleep satisfaction of patients in observation group was 98.55%,which was significantly higher than 85.51%in control group(P<0.05).Conclusion:Suanzaoren Decoction combined with Dexzopiclone has a good effect on patients with insomnia with"deficiency of liver blood and internal disturbance of deficient heat",and can improve their sleep quality,sleep satisfaction and HAMA and HAMD scores,with high safety.