孕康口服液结合黄体酮治疗习惯性流产患者的效果及对E2水平的影响

Effect of Yunkang oral liquid combined with progesterone on patients with habitual abortion and its influence on E2 level

目的探讨孕康口服液结合黄体酮治疗习惯性流产患者的效果及对雌二醇(E2)水平的影响。方法选取2021年9月至2022年9月进入本院治疗的100例习惯性流产患者作为研究对象,以随机数字表法将其分为对照组与观察组,各50例。对照组给予黄体酮治疗,观察组给予孕康口服液结合黄体酮治疗。比较两组的治疗效果。结果治疗前,两组的E2、孕酮(P)、人绒毛膜促性腺激素(β-HCG)及卵泡刺激素(FSH)水平比较,差异无统计学意义(P>0.05);治疗后,两组的E2、P、β-HCG及FSH水平均升高,且观察组高于对照组,差异具有统计学意义(P<0.05)。观察组的阴道止血时间、下腹部疼痛消退时间、腹胀症状消退时间、腰酸症状消退时间及住院时间均短于对照组(P<0.05)。治疗前,两组的可溶性人类白细胞抗原G(sHLA-G)、转化生长因子(TGF-β1)及孕激素诱导封闭因子(PIBF)水平比较,差异无统计学意义(P>0.05);治疗后,两组的sHLA-G、TGF-β1及PIBF水平均升高,且观察组高于对照组,差异具有统计学意义(P<0.05)。结论孕康口服液结合黄体酮可改善习惯性流产患者的激素及免疫指标水平,促进疾病症状消退,值得推广。

Objective To explore the effect of Yunkang oral liquid combined with progesterone on patients with habitual abortion and its influence on estradiol(E2)level.Methods A total of 100 patients with habitual abortion who were admitted in our hospital from September 2021 to September 2022 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 50 cases in each group.The control group was treated with progesterone,and the observation group was treated with Yunkang oral liquid combined with progesterone.The therapeutic effects of the two groups were compared.Results Before treatment,there were no significant differences in the levels of E2,progesterone(P),β-human chorionic gonadotropin(β-HCG)and follicle-stimulating hormone(FSH)between the two groups(P>0.05);after treatment,the levels of E2,P,β-HCG and FSH in the two groups increased,and those in the observation group were higher than the control group,the differences were statistically significant(P<0.05).The vaginal hemostasis time,lower abdominal pain regression time,abdominal distension symptom regression time,lumbar acid symptom regression time and hospitalization time in the observation group were shorter than those in the control group(P<0.05).Before treatment,there were no significant differences in the levels of soluble human leukocyte antigen-G(sHLA-G),transforming growth factor-β1(TGF-β1)and progesterone-induced blocking factor(PIBF)between the two groups(P>0.05);after treatment,the levels of sHLA-G,TGF-β1 and PIBF in the two groups increased,and those in the observation group were higher than the control group,the differences were statistically significant(P<0.05).Conclusion Yunkang oral liquid combined with progesterone can improve the hormones and immune indexes levels of patients with habitual abortion,and promote the regression of disease symptoms,which is worthy of promotion.