血清PCT、MCP-1水平与新生儿细菌性败血症严重程度的相关性及诊断价值

Correlation and diagnostic value of serum PCT and MCP-1 levels with the severity of neonatal bacterial sepsis

目的分析血清降钙素原(PCT)、单核细胞趋化蛋白-1(MCP-1)与新生儿细菌性败血症严重程度的相关性及诊断价值。方法选取新生儿细菌性败血症患者100例作为研究组,同期普通细菌感染新生儿患者100例作为对照组。比较两组入组时的血清PCT水平、MCP-1水平、SOFA评分、PCIS评分,分析血清PCT水平、MCP-1水平与新生儿细菌性败血症病情严重程度(SOFA评分、PCIS评分)的相关性。分析血清PCT水平、MCP-1水平联合检测在新生儿细菌性败血症诊断中的价值。结果入组时,研究组血清PCT水平、MCP-1水平、SOFA评分高于对照组,PCIS评分低于对照组,差异均具有统计学意义(P<0.05);血清PCT、MCP-1水平与SOFA评分呈正相关,而与PCIS评分呈负相关(P<0.05);血清PCT、MCP-1水平联合诊断新生儿细菌性败血症的ROC曲线下面积(AUC)大于单项指标诊断(P<0.05)。结论血清PCT、MCP-1水平与新生儿细菌性败血症病情严重程度密切相关,其联合检测对新生儿细菌性败血症具有较高的诊断价值。

Objective To analyze the correlation and diagnostic value between serum procalcitonin(PCT),monocyte chemotactic protein-1(MCP-1),and the severity of neonatal bacterial sepsis.Methods 100 neonates with bacterial sepsis were selected as the study group,and 100 neonates with common bacterial infections during the same period served as the control group.The serum PCT levels,MCP-1 levels,SOFA scores,and PCIS scores of two groups at enrollment were compared,and analyzed the correlation between serum PCT and MCP-1 levels and the severity of neonatal bacterial sepsis(SOFA score,PCIS score)were compared.The value of combined detection of serum PCT and MCP-1 levels in the diagnosis of neonatal bacterial sepsis were analyzed.Results When enrolled,the serum levels of PCT,MCP-1,and SOFA in the study group were higher than those in the control group,while the PCIS score was lower than that in the control group,with a statistically significant difference(P<0.05).The levels of serum PCT and MCP-1 were positively correlated with SOFA score,but negatively correlated with PCIS score(P<0.05).The area under the ROC curve(AUC)of the combined diagnosis of serum PCT and MCP-1 levels for neonatal bacterial sepsis was greater than that of single indicator diagnosis(P<0.05).Conclusion The serum levels of PCT and MCP-1 are closely related to the severity of neonatal bacterial sepsis,and their combined detection has high diagnostic value for neonatal bacterial sepsis.