杂合式血液净化序贯疗法与丹参注射液联合治疗重症急性胰腺炎的效果分析

Analysis of the efficacy of hybrid blood purification sequential therapy combined with Danshen injection in the treatment of severe acute pancreatitis

目的分析杂合式血液净化序贯疗法与丹参注射液联合治疗重症急性胰腺炎(SAP)的效果。方法98例SAP患者,使用随机数字表法分为对照组(49例)与研究组(49例)。两组均接受基础治疗,对照组应用杂合式血液净化序贯疗法,研究组在其基础上联合丹参注射液治疗。比较两组患者的临床疗效、症状与体征改善时间、不良反应发生情况。结果研究组患者总有效率95.92%高于对照组的81.63%(P<0.05)。研究组腹痛腹胀消失时间、血尿淀粉酶恢复正常时间、尿恢复正常时间、体温恢复正常时间分别为(4.23±0.95)、(4.15±1.06)、(6.00±0.92)、(5.02±0.85)d,均短于对照组的(6.00±0.86)、(6.45±1.09)、(7.56±1.00)、(6.50±0.79)d(P<0.05)。两组不良反应发生率比较未见差异性(P>0.05)。结论杂合式血液净化序贯疗法与丹参注射液联合治疗SAP效果确切,能够促进患者症状与体征恢复,具有临床推广价值。

Objective To analyze the efficacy of hybrid blood purification sequential therapy combined with Danshen injection in the treatment of severe acute pancreatitis(SAP).Methods 98 SAP patients were divided into a control group(49 cases)and a study group(49 cases)according to random number table.Both groups received basic treatment,on this basis,the control group was treated with hybrid blood purification sequential therapy,and the study group was treated with Danshen injection.The clinical efficacy,improvement time of symptoms and signs and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of 95.92%in the study group was higher than 81.63%in the control group(P<0.05).The disappearance time of abdominal pain and distension,the recovery time of blood and urine amylase,and the recovery time of body temperature were(4.23±0.95),(4.15±1.06),(6.00±0.92)and(5.02±0.85)d in the study group,which were shorter than(6.00±0.86),(6.45±1.09),(7.56±1.00)and(6.50±0.79)d in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of hybrid blood purification sequential therapy and Danshen injection in the treatment of SAP has a definite effect,which can promote the recovery of symptoms and signs,and has the value of clinical promotion.