自体富血小板血浆治疗薄型子宫内膜的研究进展

Research progress of autologous platelet-rich plasma in the treatment of thin endometrium

薄型子宫内膜降低了临床妊娠率和成活率,严重威胁着人类的生殖健康。目前临床上尚无改善子宫内膜厚度的最佳治疗方案,尤其是对于部分顽固性薄型子宫内膜更是治疗效果欠佳。自体富血小板血浆(PRP)含有大量生长因子,可通过促进子宫内膜细胞的增殖和迁移、促进血管的生成来改善子宫内膜的厚度,进而成为治疗薄型子宫内膜新的有效方法。本文对PRP的制备方法、治疗薄型子宫内膜的作用机制及治疗薄型子宫内膜的应用进展做一综述,为选择合适的方法制备自体PRP用于治疗薄型子宫内膜提供理论参考依据。

Thin endometrium can reduce the clinical pregnancy rate and live birth rate,and seriously affect human reproductive health.At present,there is no optimal treatment plan for improving endometrial thickness in clinical practice,especially for some stubborn thin endometrium,the treatment effect is not satisfactory.Autologous platelet-rich plasma(PRP)contains a large amount of growth factors,which can improve the thickness of the endometrium by promoting the proliferation and migration of endometrial cells and the generation of blood vessels,thus becoming a new and effective method for treating thin endometrium.This article provides a review of the preparation methods and mechanism of action of PRP in treating thin endometrium,and the application progress of PRP in treating thin endometrium,aiming to provide a theoretical reference for selecting appropriate methods to prepare autologous PRP for treating thin endometrium.