去氧孕烯炔雌醇与地屈孕酮治疗青春期子宫异常出血患者的效果比较

Comparison of effects of Desogestrel and Ethinylestradiol and Dydrogesterone in treatment of adolescent patients with abnormal uterine bleeding

目的:比较去氧孕烯炔雌醇与地屈孕酮治疗青春期子宫异常出血患者的效果。方法:回顾性分析2021年1月至2023年1月该院收治的60例青春期子宫异常出血患者的临床资料,根据治疗药物不同将其分为对照组和观察组各30例。对照组采用地屈孕酮治疗,观察组采用去氧孕烯炔雌醇治疗。比较两组临床疗效、控制出血和止血时间、性激素指标[孕酮、卵泡刺激素(FSH)、雌二醇(E_(2))、促黄体生成素(LH)]水平、临床症状(痛经、经前期综合征)评分、月经情况(月经周期、月经量)和并发症发生率。结果:两组治疗总有效率比较,差异无统计学意义(P>0.05);观察组控制出血时间短于对照组,出血量少于对照组,差异均有统计学意义(P<0.05);两组孕酮、FSH、E_(2)、LH水平均低于治疗前,但组间比较,差异无统计学意义(P>0.05);两组痛经、经前期综合征等临床症状评分均低于治疗前,且观察组低于对照组,两组月经周期均短于治疗前,但观察组长于对照组,两组月经量均少于治疗前,但观察组多于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率为23.33%(7/30),高于对照组的3.33%(1/30),差异有统计学意义(P<0.05)。结论:去氧孕烯炔雌醇治疗青春期子宫异常出血患者可缩短出血时间,减少出血量,降低临床症状评分的效果优于地屈孕酮治疗,但不良反应发生率、月经量和月经周期均高于地屈孕酮治疗。

Objective:To compare effects of Desogestrel and Ethinylestradiol and Dydrogesterone in treatment of adolescent patients with abnormal uterine bleeding.Methods:The clinical data of 60 adolescent patients with abnormal uterine bleeding admitted to this hospital from January 2021 to January 2023 were retrospectively analyzed.According to different therapeutic drugs,they were divided into control group and observation group,30 cases in each group.The control group was treated with Dydrogesterone,while the observation group was treated with Desogestrel and Ethinylestradiol.The clinical efficacy,the bleeding control and the hemostasis time,the sex hormone indexes[progesterone,follicle stimulating hormone(FSH),estradiol(E_(2)),luteinizing hormone(LH)]levels,the clinical symptoms(dysmenorrhea,premenstrual syndrome)scores,the menstrual conditions(menstrual cycle,menstrual volume),and incidence of complications were compared between the two groups.Results:There was no significant difference in the total effective rate between the two groups(P>0.05).The bleeding control time in the observation group was shorter than that in the control group,the amount of bleeding was less than that in the control group,and the differences were statistically significant(P<0.05).The levels of progesterone,FSH,E_(2) and LH in the two groups were lower than those before the treatment;however,there were no significant differences between the two groups(P>0.05).The scores of clinical symptoms such as dysmenorrhea and premenstrual syndrome in the two groups were lower than those before treatment,and that in the observation group was lower than that in the control group;the menstrual cycle of the two groups were shorter than those before treatment,but that in the observation group was longer than that in the control group;the menstrual volume of the two groups were less than those before the treatment,but that in the observation group was more than that in the control group;and the differences were statistically significant(P<0.05).Further,the incidence of adverse reactions in the observation group was 23.33%(7/30),which was higher than 3.33%(1/30)in the control group,and the difference was statistically significant(P<0.05).Conclusions:Desogestrel and Ethinylestradiol in the treatment of the adolescent patients with abnormal uterine bleeding can shorten the bleeding time,reduce the amount of bleeding,reduce the clinical symptom scores,It is superior to single Dydrogesterone,but the incidence of adverse reactions,the menstrual volume and prolong the menstrual cycle are higher than those of Dydrogesterone treatment.