血清Hcy、hs-CRP、D-D水平与妊娠期高血压疾病患者病情严重程度的相关性

Correlations among serum Hcy,hs-CRP,D-D levels and severity of patients with hypertensive disorder complicating pregnancy

目的:分析血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)水平与妊娠期高血压疾病患者病情严重程度的相关性。方法:回顾性分析2022年3月至2023年3月商丘仁和中医院收治的98例妊娠期高血压疾病患者的临床资料,设为观察组,另选取同期进行日常产检的91名健康妊娠者设为对照组,比较两组血清Hcy、hs-CRP、D-D水平;并根据病情严重程度将其分为妊娠期高血压患者54例、子痫前期患者24例、子痫患者20例,比较不同严重程度妊娠期高血压疾病患者血清Hcy、hs-CRP、D-D水平,分析其与妊娠期高血压疾病患者病情严重程度的相关性。结果:观察组血清Hcy、hs-CRP、D-D水平均高于对照组,差异有统计学意义(P<0.05);血清Hcy、hs-CRP、D-D水平,妊娠期高血压患者<子痫前期患者<子痫患者,差异均有统计学意义(P<0.05);Pearson相关性分析结果显示,血清Hcy、hs-CRP、D-D水平与妊娠期高血压疾病患者病情严重程度均呈正相关(r>0,P<0.05)结论:血清Hcy、hs-CRP、D-D水平与妊娠期高血压疾病患者病情严重程度均呈正相关。

Objective:To analyze correlations among serum homocysteine(Hcy),high-sensitivity C-reactive protein(hs-CRP),D-dimer(D-D)levels and severity of patients with hypertensive disorder complicating pregnancy.Methods:The clinical data of 98 patients with hypertensive disorder complicating pregnancy admitted to Shangqiu Renhe Hospital of Traditional Chinese Medicine from March 2022 to March 2023 were retrospectively analyzed and they were set as the observation group;and 91 healthy pregnant women who underwent routine prenatal examination during the same period were selected as the control group.The levels of serum Hcy,hs-CRP and D-D were compared between the two groups.According to the severity of the disease,they were divided into 54 cases of gestational hypertension group,24 cases of preeclampsia group and 20 cases of eclampsia group.The levels of serum Hcy,hs-CRP and D-D in the patients with hypertensive disorder complicating pregnancy of different severity were compared.The correlations among the levels of serum Hcy,hs-CRP and D-D and the severity of hypertensive disorder complicating pregnancy were analyzed.Results:The levels of serum Hcy,hs-CRP and D-D in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The comparison of the levels of serum Hcy,hs-CRP and D-D showed that:gestational hypertension group<preeclampsia group<eclampsia group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the serum Hcy,hs-CRP and D-D levels were positively correlated with the severity of hypertensive disorder complicating pregnancy(r>0,P<0.05).Conclusions:The serum Hcy,hs-CRP and D-D levels are positively correlated with the severity of hypertensive disorder complicating pregnancy.