甘精胰岛素联合瑞格列奈治疗老年2型糖尿病的效果分析

Analysis on Effect of Insulin Glargine Combined with Repaglinide in Treatment of Elderly Type 2 Diabetes Mellitus

目的:分析甘精胰岛素联合瑞格列奈治疗老年2型糖尿病的效果。方法:选取2020年1月—2022年12月北京市第二医院收治的老年2型糖尿病患者92例作为研究对象,随机分为联合组与长效组,各46例。长效组给予甘精胰岛素治疗,联合组在长效组基础上给予瑞格列奈治疗。比较两组治疗效果。结果:治疗后,两组空腹血糖、餐后2 h血糖及糖化血红蛋白水平低于治疗前,且联合组低于长效组,差异有统计学意义(P<0.05)。治疗后,两组空腹血糖达标率、餐后2 h血糖达标率及糖化血红蛋白达标率高于治疗前,且联合组高于长效组,差异有统计学意义(P<0.05)。治疗后,两组空腹胰岛素、稳态模型胰岛素抵抗指数低于治疗前,且联合组低于长效组,两组胰岛β细胞功能指数高于治疗前,且联合组高于长效组,差异有统计学意义(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P=0.819)。结论:甘精胰岛素联合瑞格列奈治疗老年2型糖尿病的效果显著,能够改善患者血糖水平,提高血糖达标率,改善胰岛功能,且安全性较高。

Objective:To analyze the effect of insulin glargine combined with repaglinide in the treatment of type 2 diabetes melli⁃tus in the elderly.Methods:A total of 92 elderly patients with type 2 diabetes mellitus who were admitted to Beijing Second Hospi⁃tal from January 2020 to December 2022 were selected as the study subjects.They were randomly divided into combination group and long-acting group,with 46 cases in each group.The long-acting group was treated with insulin glargine,and the combination group was treated with repaglinide on the basis of the long-acting group.The treatment effects were compared between the two groups.Results:After treatment,the fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin levels in the two groups were lower than those before treatment,and the levels in the combination group were lower than those in the longacting group,with a statistically significant difference(P<0.05).After treatment,the fasting blood glucose compliance rate,2 h post⁃prandial blood glucose compliance rate and glycosylated hemoglobin compliance rate in the two groups were higher than those be⁃fore treatment,and the compliance rates in the combination group were higher than those in the long-acting group,with a statisti⁃cally significant difference(P<0.05).After treatment,the fasting insulin and homeostasis model insulin resistance index in the two groups were lower than those before treatment,and these indexes in the combination group were lower than those in the long-acting group,while the pancreaticβcell function index in the two groups was higher than that before treatment,and this index in the com⁃bination group was higher than that in the long-acting group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P=0.819).Conclusion:Insulin glargine combined with repaglinide has a significant effect in the treatment of elderly type 2 diabetes mellitus,and can improve the blood glucose level,increase the blood glucose compliance rate,and improve the function of pancreatic islets,with a high safety.