右美托咪定与七氟烷在剖宫产产妇全身麻醉中的应用效果比较

Comparison of Application Effects of Dexmedetomidine and Sevoflurane in General Anesthesia for Cesarean Section Women

目的:分析右美托咪定与七氟烷在剖宫产产妇全身麻醉中的应用效果。方法:选取2020年7月—2021年7月拟于包钢第三职工医院行剖宫产术的产妇100例作为研究对象,采用单双数字分组法随机分为对照组与观察组,各50例。两组均实施全身麻醉,对照组给予右美托咪定,观察组给予七氟烷。比较两组麻醉效果。结果:麻醉诱导开始、手术切口开始、手术结束后,两组收缩压、舒张压、心率比较,差异无统计学意义(P>0.05)。观察组麻醉起效时间短于对照组,术后苏醒时间早于对照组,差异有统计学意义(P<0.001)。术前,两组肾上腺素、去甲肾上腺素及皮质醇水平比较,差异无统计学意义(P>0.05)。手术切口开始时,两组肾上腺素、皮质醇水平高于术前,但对照组低于观察组;对照组去甲肾上腺素低于术前,观察组去甲肾上腺素高于术前,差异均有统计学意义(P<0.05)。术后,两组肾上腺素、去甲肾上腺素水平均高于术前,但对照组低于观察组,差异有统计学意义(P<0.05)。结论:右美托咪定与七氟烷在剖宫产产妇全身麻醉中对血流动力学指标的影响较小,安全性高。七氟烷麻醉诱导迅速,停药后苏醒较快;右美托咪定则能够减轻产妇应激反应。临床可综合判断实际需求及产妇麻醉适应情况选择麻醉药。

Objective:To analyze the application effect of dexmedetomidine and sevoflurane in general anesthesia for cesarean section.Methods:A total of one hundred women who planned to have cesarean section in Baotou Bao Steel Third Employee Hospital from July 2020 to July 2021 were selected as the research objects,and were randomly divided into the control group and the observation group with fifty cases in each group by using the single and even digital classification method.Both groups were given general anesthesia,the control group was given dexmedetomidine,and the observation group was given sevoflurane.The anesthetic effect of the two groups was compared.Results:There was no significant difference in systolic blood pressure,diastolic blood pressure and heart rate between the two groups at the beginning of anesthesia induction,the beginning of surgical incision and the end of surgery(P>0.05);the onset time of anesthesia in the observation group was shorter than that in the control group,and the postoperative recovery time was earlier than that in the control group,the difference was statistically significant(P<0.001);before operation,there was no significant difference in the levels of epinephrine,norepinephrine and cortisol between the two groups(P>0.05);at the beginning of surgical incision,the levels of adrenaline and cortisol in both groups were higher than before surgery,but the control group was lower than the observation group,the control group was lower than before surgery,and the observation group was higher than before surgery,with statistical significance(P<0.05);after operation,the level of adrenaline,norepinephrine in both groups was higher than that before operation,but the control group was lower than the observation group,the difference was statistically significant(P<0.05).Conclusion:Dexmedetomidine and sevoflurane have little effect on hemodynamic indexes during general anesthesia in cesarean section,and have high safety.Sevoflurane anesthesia induction is rapid,the recovery after withdrawal is faster.Dexmedetomide prescription can reduce maternal stress response.Clinical anesthetics can be selected by judging the actual needs and the parturients'adaptation to anesthesia.