Toll样受体家族在IgA肾病中的研究进展

Research progress of Toll like receptor family in IgA nephropathy

越来越多的研究证实Toll样受体(TLR)家族在IgA肾病(IgAN)的发病机制中发挥重要作用,且TLRs与IgAN的临床表型及肾脏病理改变密切相关,因此,TLRs可能成为新的无创性生物学标志物和新的治疗靶点。然而,TLR家族成员众多,其在IgAN发病与进展不同阶段的作用尚未完全阐明。因此,该文就TLRs在IgAN中的作用机制,以及其作为潜在生物学标志物及治疗靶点的研究进展进行综述,以期为TLRs在IgAN中的进一步研究提供科学依据。

Many studies have confirmed that the Toll like receptor(TLR)family plays an important role in the pathogenesis of IgA nephropathy(IgAN),and TLRs are closely related to the clinical phenotype and renal pathological changes of IgAN.Therefore,TLRs may become new non-invasive biomarkers and therapeutic targets.However,there are numerous members of the TLR family,and their roles in the pathogenesis and progression of IgAN at different stages have not been fully elucidated.Therefore,this article reviews the mechanism of action of TLRs in IgAN,as well as their research progress as potential biomarkers and therapeutic targets,in order to provide scientific basis for further research on TLRs in IgAN.