腹腔镜直肠全系膜切除联合动脉置泵灌注化疗治疗中晚期直肠癌患者的疗效观察

Therapeutic Effect of Laparoscopic Total Mesangial Rectal Resection Combined with Arterial Pump Infusion Chemotherapy on Patients with Middle and Advanced Rectal Cancer

目的:分析在为中晚期直肠癌(rectalcancer,RC)患者实施治疗的过程中腹腔镜直肠全息膜切除术(totalmesorectal excision,TME)+动脉置泵灌注化疗的临床疗效。方法:本研究随机在医院接受中晚期RC治疗的患者中选取48例开展实验研究,根据患者治疗方案的不同将其分为观察组(n=24,治疗方案:腹腔镜直肠TME+动脉置泵灌注化疗)与对照组(n=24,治疗方案:腹腔镜直肠TME)。结果:两组患者治疗前生存质量、并发症发生率并无显著差异,P>0.05。观察组患者术后相关指标、临床疗效、并发症发生率以及治疗后生存质量均与对照组患者存在显著差异,P<0.05。结论:在实施中晚期RC患者治疗的过程中腹腔镜直肠TME联合动脉置泵灌注化疗的应用有助于患者术后指标的改善,在提高临床疗效、治疗后生活质量的同时减少了围术期并发症的出现。

Objective:To analyze the clinical efficacy of total mesorectal excision(TME)+arterial pump infusion chemotherapy in the treatment of rectal cancer(RC)patients.Methods:In this study,48 patients who received RC treatment in the hospital were randomly selected to carry out the experimental study,and were divided into observation group(n=24,treatment plan:laparoscopic rectal TME+arterial pump infusion chemotherapy)and control group(n=24,treatment plan:laparoscopic rectal TME)according to different treatment plans.Results:There were no significant differences in quality of life and incidence of complications between the two groups before treatment(P>0.05).There were significant differences in postoperative indexes,clinical efficacy,complication rate and quality of life after treatment between observation group and control group(P<0.05).Conclusion:The application of laparoscopic rectal TME combined with arterial pump infusion chemotherapy in the treatment of RC patients in the middle and late stage is helpful to improve the postoperative indicators of patients,improve the clinical efficacy,improve the quality of life after treatment,and reduce the occurrence of perioperative complications.