自拟温经通络汤治疗腰椎间盘突出症的临床效果

Clinical effect of Self-designed Wenjing Tongluo Decoction in the treatment of lumbar disc herniation

目的 探讨自拟温经通络汤治疗腰椎间盘突出症的临床效果。方法 选取2020年2月至2022年12月四川省眉山市中医医院收治的122例腰椎间盘突出症患者为研究对象,按照随机数字表法将其分为对照组和观察组,各61例。对照组以靶点射频热凝术治疗,观察组增加自拟温经通络汤治疗。两组均治疗3个疗程。评价两组临床疗效。比较两组治疗前后中医症候积分、表面肌电图水平[左侧积分肌电值(iEMG)、右侧iEMG、左侧平均功率频率(MPF)、右侧MPF]、炎症因子水平[基质金属蛋白酶-7(MMP-7)、缺氧诱导因子-2α(HIF-2α)、前列腺素E_(2)(PGE_(2))]及不良反应总发生率。结果 观察组临床疗效优于对照组(P<0.05)。治疗后,两组中医证候积分均低于治疗前,且观察组低于对照组(P<0.05)。治疗后,两组左侧iEMG、右侧iEMG、左侧MPF、右侧MPF均高于治疗前,且观察组高于对照组(P<0.05)。治疗后,两组MMP-7、HIF-2α、PGE_(2)水平均较治疗前降低,且观察组低于对照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论 自拟温经通络汤治疗腰椎间盘突出症效果良好,可改善患者中医症候,提高腰椎部肌电图指标水平,抑制炎症因子表达,治疗安全性良好。

Objective To explore the clinical effect of Self-designed Wenjing Tongluo Decoction in the treatment of lumbar disc herniation.Methods A total of 122 patients with lumbar disc herniation admitted to Meishan Traditional Chinese Medicine Hospital from February 2020 to December 2022 were selected as subjects and they were divided into control group and observation group by random number table method,with 61 cases in each group.The control group was treated with targeted radiofrequency thermocoagulation,while the observation group was treated with Self-designed Wenjing Tongluo Decoction.Both groups were treated for three courses.The clinical effect of the two groups was evaluated.Traditional Chinese medicine symptom score,surface electromyography level(lelt side integrated electromyography [i EMG],right side iEMG,left-side mean power frequency [MPF],right side MPF),inflammatory factor level(matrix metalloproteinase-7 [MMP-7],hypoxia inducible factor-2 α[HIF-2α],prostaglandin E_2[PGE_2]),and treatment safety were compared between the two groups before and after treatment.Results The clinical effect of the observation group was better than that of the control group(P<0.05).After treatment,traditional Chinese medicine syndrome scores in both groups were lower than those before treatment,and those in observation group were lower than those in control group(P<0.05).After treatment,left side i EMG,right side i EMG,left side MPF,and right side MPF in both groups were higher than those before treatment,and those in observation group were higher than those in the control group(P<0.05).After treatment,the levels of MMP-7,HIF-2α,and PGE_(2) in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).There was no significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion The Self-designed Wenjing Tongluo Decoction has good therapeutic effect on lumbar disc herniation,which can improve traditional Chinese medicine symptoms,increase the level of electromyographic indicators in the lumbar spine,inhibit the expression of inflammatory factors,and has good treatment safety.