血脂水平检测在冠心病诊断中的临床意义

Clinical Significance of lipid Level Tests in Diagnosis of Patients with Coronary Heart Disease

目的:探讨检测血脂异常在冠心病诊断中的临床意义.方法:选取2021年1月至2023年1月本院收治的87例冠心病患者作为研究对象,纳入研究组.同期在本院健康体检的87例健康受试者作为对照,纳入对照组.比较两组入院时血脂[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白B(APOB)、载脂蛋白A1(APOA1)]水平,对比其与冠心病病情相关性及临床诊断价值.结果:入院时研究组患者的血清TC、TG、LDL-C、APOB、APOA1水平,均显著高于对照组,HDL-C水平,则显著低于对照组,差异均有统计学意义(P<0.05);入院时研究组患者的血清TC、TG、LDL-C、APOB、APOA1水平异常,与患者冠心病严重程度、阳性冠状动脉病变支数、冠状动脉狭窄程度Gensini评分,均呈正相关关系,而血清HDL-C水平,则与冠心病严重程度、阳性冠状动脉病变支数、冠状动脉狭窄程度Gensini评分,呈负相关关系(P<0.05).结论:血清TC、TG、LDL-C、HDL-C、APOB、APOA1水平,与冠心病患者的病情程度密切相关,临床检测其水平对评估冠心病患者的病情具有重要临床意义.

Objective:To investigate the clinical significance of testing the levels of various indexes of blood lipids in the diagnosis of coronary heart disease.Methods:Eighty-seven patients with coronary artery disease in our hospital from January 2021 to January 2023 were selected as the study group,and 87 healthy medical examiners in the same period were selected as the control group.Compared the levels of blood lipids[total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),apolipoprotein B(APOB),apolipoprotein A1(APOA1)] between the two groups at admission,and compared their correlation with disease severity and diagnostic value.Results:At admission,the serum TC,TG,LDL-C,APOB,and APOA1 levels in the study group were higher than those in the control group,while the HDL-C level was lower,and the differences were statistically significant(P<0.05).At admission,the serum TC,TG,LDL-C,APOB,and APOA1 levels were positively correlated with coronary heart disease,the number of diseased vessels,and the Gensini score,while the serum HDL-C level was negatively correlated with coronary heart disease,the number of diseased vessels,and the Gensini score,the differences were statistically significant(P<0.05).Conclusion:Serum TC,TG,LDL-C,HDL-C,APOB,and APOA1 levels are closely related to the degree of coronary artery disease,and clinical detection of their expression is of great significance in evaluating patients'conditions.