2型糖尿病患者吸烟与代谢相关脂肪性肝病关系的研究

The association between smoking and metabolic associated fatty liver disease in patients with type 2 diabetes mellitus

目的:探讨2型糖尿病(T2DM)患者中吸烟与代谢相关脂肪性肝病(MAFLD)之间的关系。方法:选取2020年12月至2023年3月在东南大学附属中大医院内分泌科住院的1466例T2DM患者为研究对象。收集患者的一般资料和实验室指标,并使用脂肪肝指数(FLI)评估肝脏脂肪积累,将患者分为MAFLD组和非MAFLD组进行比较。采用Logistic回归分析探讨吸烟与MAFLD的关系。结果:MAFLD组的患者男性占比更多,年龄更小,病程也更短;其尿酸、甘油三酯和总胆固醇血清水平更高,高密度脂蛋白水平较低。MAFLD组吸烟患者占比更高(42.1%vs.28.9%,P<0.001)。在校正性别、年龄、病程、糖化血红蛋白、体质指数(BMI)后,吸烟仍是T2DM患者发生MAFLD的危险因素。结论:吸烟是T2DM患者发生MAFLD的危险因素。

Objective:To investigate the association between smoking and metabolism-associated fatty liver disease(MAFLD)in patients with type 2 diabetes mellitus(T2DM).Methods:A total of 1466 inpatients with T2DM from Department of Endocrinology at Zhongda Hospital were enrolled in this study.Demographic characteristics and laboratory data were collected.Hepatic fat accumulation was assessed by fatty liver index(FLI).According to FLI,patients were categorized into MAFLD and non-MAFLD groups.We analysed the association between smoking and MAFLD with multivariable Logistic regression.Results:Patients in MAFLD group were predominantly male,younger,and had a shorter disease duration.Serum levels of uric acid,triglycerides,and total cholesterol were higher and level of high-density lipoproteins was lower in those with MAFLD.Prevalence of smokers was higher in MAFLD group(42.1%vs.28.9%,P<0.001).After adjusting for gender,age,disease duration,glycemic control,and BMI,smoking was still a significant risk factor for MAFLD in patients with T2DM.Conclusion:Smoking was a risk factor in the development of MAFLD in participants with T2DM.