不同保存条件下呋喃丹标准储备液稳定性研究

Study on Stability of Carbofuran Standard Stock Solution under Different Preservation Conditions

研究呋喃丹标准储备液在不同保存条件下稳定性。将呋喃丹标准品配制成浓度为0.1μg/mL、0.2μg/mL、8.0μg/mL的标准品储备液,贮藏在20℃、4℃、-20℃条件下,分别于保存0 d、10 d、20 d、34 d取上述样品,多反应离子检测(MRM),气相色谱-质谱联用(GC-MS/MS)法检测其呋喃丹含量。呋喃丹的标准储备液在20℃、4℃和-20℃保存条件下均可发生分解,-20℃条件下分解速度最慢,4℃次之,20℃分解速度最快,高浓度较低浓度分解速度慢。呋喃丹标准储备液应在-20℃且高浓度条件下保存,且得到不同温度不同浓度保存条件下呋喃丹标准储备液存放的有效期,为呋喃丹中毒案件的法医学鉴定中标准溶液保存和检测结果的可靠性提供实验依据。

To study the stability of carbofuran standard stock solution under different preservation conditions,and to provide experimental basis for the preservation of standard solution and the reliability of test results in forensic identification of carbofuran poisoning cases,carbofuran standard was prepared into standard stock solutions with concentrations of 0.1μg/mL,0.2μg/mL and 8.0μg/mL,which were stored in refrigerators at 20℃,4℃ and -20℃,and the samples were taken at 0,10,20 and 34 days respectively,and were detected by multiple reaction ion detection(MRM)and gas chromatography.The standard stock solution of carbofuran can be decomposed at -20℃,4℃ and 20℃,and the decomposition rate is the slowest at -20℃,followed by 4℃,and the decomposition rate was the fastest at 20℃,and the decomposition rate of high concentration was slower than that of low concentration.The carbofuran standard stock solution should be stored at -20℃ and high concentration,and the storage period of carbofuran standard stock solution at different temperatures and concentrations can be obtained.